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Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis
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SYSNO ASEP 0534437 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis Author(s) Levada, K. (RU)
Pshenichnikov, S. (RU)
Omelyanchik, A. (RU)
Rodionova, V. (RU)
Nikitin, A. (RU)
Savchenko, A. (RU)
Schetinin, I. (RU)
Zhukov, D. (RU)
Abakumov, M. (RU)
Majouga, A. (RU)
Lunova, Mariia (FZU-D) ORCID
Jirsa, M. (CZ)
Smolková, Barbora (FZU-D) ORCID
Uzhytchak, Mariia (FZU-D) ORCID
Dejneka, Alexandr (FZU-D) RID, ORCID
Lunov, Oleg (FZU-D) ORCIDNumber of authors 16 Article number 17 Source Title Nano Convergence. - : Springer - ISSN 2196-5404
Roč. 7, č. 1 (2020), s. 1-17Number of pages 17 s. Language eng - English Country US - United States Keywords cytotoxicity ; apoptosis ; autophagy ; iron oxide nanoparticles ; magnetic resonance imaging Subject RIV BO - Biophysics OECD category Biophysics R&D Projects LTC19040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support FZU-D - RVO:68378271 UT WOS 000533789500001 EID SCOPUS 85085679530 DOI 10.1186/s40580-020-00228-5 Annotation Iron oxide nanoparticles (IONs) are frequently used in various biomedical applications, in particular as magnetic resonance imaging contrast agents in liver imaging. Indeed, number of IONs have been withdrawn due to their poor clinical performance. Yet comprehensive understanding of their interactions with hepatocytes remains relatively limited. Here we investigated how iron oxide nanocubes (IO-cubes) and clusters of nanocubes (IO-clusters) affect distinct human hepatic cell lines. The viability of HepG2, Huh7 and Alexander cells was concentration-dependently decreased after exposure to either IO-cubes or IO-clusters. We found similar cytotoxicity levels in three cell lines triggered by both nanoparticle formulations. Our data indicate that different expression levels of Bcl-2 predispose cell death signaling mediated by nanoparticles. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2021 Electronic address https://doi.org/10.1186/s40580-020-00228-5
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