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Human metabolite-derived alkylsuccinate/dilinoleate copolymers: from synthesis to application

SYSNO ASEP	0534436
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Human metabolite-derived alkylsuccinate/dilinoleate copolymers: from synthesis to application
Author(s)	Jäger, Alessandro (UMCH-V)_{RID, ORCID} Donato, Ricardo Keitel (UMCH-V)_ORCID Perchacz, Magdalena (UMCH-V)_RID Donato, Katarzyna Zawada (UMCH-V) Starý, Zdeněk (UMCH-V)_RID Konefal, Rafal (UMCH-V)_{RID, ORCID} Serkis-Rodzen, Magdalena (UMCH-V)_RID Raucci, M. G. (IT) Fuentefria, A. M. (BR) Jäger, Eliezer (UMCH-V)_{ORCID, RID}
Source Title	Journal of Materials Chemistry B - ISSN 2050-750X Roč. 8, č. 43 (2020), s. 9980-9996
Number of pages	17 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	biocompatible ; biodegradable ; polyesters
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GJ20-13946Y GA ČR - Czech Science Foundation (CSF)
	GJ20-15077Y GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013
UT WOS	000588549200015
EID SCOPUS	85096033832
DOI	10.1039/D0TB02068K
Annotation	The advances in polymer chemistry have allowed the preparation of biomedical polymers using human metabolites as monomers that can hold unique properties beyond the required biodegradability and biocompatibility. Herein, we demonstrate the use of endogenous human metabolites (succinic and dilinoleic acids) as monomeric building blocks to develop a new series of renewable resource-based biodegradable and biocompatible copolyesters. The novel copolyesters were characterized in detail employing several standard techniques, namely 1H NMR, 13C NMR, and FTIR spectroscopy and SEC, followed by an in-depth thermomechanical and surface characterization of their resulting thin films (DSC, TGA, DMTA, tensile tests, AFM, and contact angle measurements). Also, their anti-fungal biofilm properties were assessed via an anti-fungal biofilm assay and the biological properties were evaluated in vitro using relevant human-derived cells (human mesenchymal stem cells and normal human dermal fibroblasts). These novel highly biocompatible polymers are simple and cheap to prepare, and their synthesis can be easily scaled-up. They presented good mechanical, thermal and anti-fungal biofilm properties while also promoting cell attachment and proliferation, outperforming well-known polymers used for biomedical applications (e.g. PVC, PLGA, and PCL). Moreover, they induced morphological changes in the cells, which were dependent on the structural characteristics of the polymers. In addition, the obtained physicochemical and biological properties can be design-tuned by the synthesis of homo- and -copolymers through the selection of the diol moiety (ES, PS, or BS) and by the addition of a co-monomer, DLA. Consequently, the copolyesters presented herein have high application potential as renewable and cost-effective biopolymers for various biomedical applications.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2021
Electronic address	https://pubs.rsc.org/en/content/articlelanding/2020/TB/D0TB02068K#!divAbstract

Number of the records: 1