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Applications of Nanobiotechnology
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SYSNO ASEP 0534391 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Synthetic Polymers Author(s) Bačáková, Lucie (FGU-C) RID, ORCID
Zikmundová, Markéta (FGU-C)
Pajorová, Julia (FGU-C)
Brož, Antonín (FGU-C) RID, ORCID, SAI
Filová, Elena (FGU-C) RID, ORCID
Blanquer, Andreu (FGU-C) RID, ORCID
Matějka, Roman (FGU-C) RID, ORCID, SAI
Štěpanovská, Jana (FGU-C) ORCID, RID
Mikeš, P. (CZ)
Jenčová, V. (CZ)
Kuželová Košťáková, E. (CZ)
Sinica, A. (CZ)Source Title Applications of Nanobiotechnology. - London : IntechOpen, 2020 / Stoytcheva Margarita ; Zlatev Roumen - ISBN 978-1-78985-978-2 Pages s. 1-29 Number of pages 29 s. Number of pages 140 Publication form Online - E Language eng - English Country GB - United Kingdom Keywords skin replacements ; wound dressings ; nanofibers ; electrospinning ; epidermis ; dermis ; keratinocytes ; fibroblasts ; stem cells ; vascularization ; cell delivery ; drug delivery ; regenerative medicine Subject RIV EI - Biotechnology ; Bionics OECD category Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction) R&D Projects GA17-02448S GA ČR - Czech Science Foundation (CSF) NV18-01-00332 GA MZd - Ministry of Health (MZ) Institutional support FGU-C - RVO:67985823 DOI 10.5772/intechopen.88744 Annotation Nanofibrous scaffolds are popular materials in all areas of tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. In this chapter, we focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is an organ with several vitally important functions, particularly barrier, thermoregulatory, and sensory functions. Nanofibrous meshes not only serve as carriers for skin cells but also can prevent the penetration of microbes into wounds and can keep appropriate moisture in the damaged skin. The nanofibrous meshes have been prepared from a wide range of synthetic and nature-derived polymers. This review is concentrated on synthetic non-degradable and degradable polymers, which have been explored for skin tissue engineering and wound healing. These synthetic polymers were often combined with natural polymers of the protein or polysaccharide nature, which improved their attractiveness for cell colonization. The nanofibrous scaffolds can also be loaded with various bioactive molecules, such as growth factors, hormones, vitamins, antioxidants, antimicrobial, and antitumor agents. In advanced tissue engineering approaches, the cells on the nanofibrous scaffolds are cultured in dynamic bioreactors enabling appropriate mechanical stimulation of cells and at air-liquid interface. This chapter summarizes recent results achieved in the field of nanofiber-based skin tissue engineering, including results of our research group. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://www.intechopen.com/books/applications-of-nanobiotechnology/nanofibrous-scaffolds-for-skin-tissue-engineering-and-wound-healing-based-on-synthetic-polymers
Number of the records: 1