Number of the records: 1
Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9H-Pyrido[2′,3′:4,5]- and Pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidines
- 1.
SYSNO ASEP 0534197 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Pyrido-Fused Deazapurine Bases: Synthesis and Glycosylation of 4-Substituted 9H-Pyrido[2′,3′:4,5]- and Pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidines Author(s) Veselovská, Lucia (UOCHB-X) ORCID
Pohl, Radek (UOCHB-X) RID, ORCID
Tloušťová, Eva (UOCHB-X) RID, ORCID
Gurská, S. (CZ)
Džubák, P. (CZ)
Hajdúch, M. (CZ)
Hocek, Michal (UOCHB-X) RID, ORCIDSource Title ACS Omega. - : American Chemical Society - ISSN 2470-1343
Roč. 5, č. 40 (2020), s. 26278-26286Number of pages 9 s. Language eng - English Country US - United States Keywords Thymidylate synthase inhibitors ; receptor tyrosine kinase ; biological activity Subject RIV CC - Organic Chemistry OECD category Organic chemistry R&D Projects GA19-08124S GA ČR - Czech Science Foundation (CSF) LM2015064 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UOCHB-X - RVO:61388963 UT WOS 000580943000083 EID SCOPUS 85094187095 DOI 10.1021/acsomega.0c04302 Annotation Two isomeric sets of 4-substituted pyridopyrrolopyrimidine nucleobases were prepared through nucleophilic substitutions or cross-coupling reactions of 4-chloropyridopyrrolopyrimidines. The corresponding 4-amino-pyridopyrrolopyrimidines were glycosylated with 5-O-tritylribose using the modified Mitsunobu protocol. Several examples of the title heterocycles showed blue or green fluorescence. Testing of the pyridopyrrolopyrimidine nucleobases for the cytotoxic effect revealed micromolar activity of 4-benzofuryl derivatives in both series, preferentially in multidrug-resistant cancers. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2021 Electronic address https://doi.org/10.1021/acsomega.0c04302
Number of the records: 1