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Phytochemical composition and in vitro biological activity of iris spp. (iridaceae): A new source of bioactive constituents for the inhibition of oral bacterial biofilms
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SYSNO ASEP 0533874 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Phytochemical composition and in vitro biological activity of iris spp. (iridaceae): A new source of bioactive constituents for the inhibition of oral bacterial biofilms Author(s) Hoang, L. (CZ)
Beneš, F. (CZ)
Fenclová, M. (CZ)
Kronusová, O. (CZ)
Švarcová, V. (CZ)
Řehořová, K. (CZ)
Baldassarre Švecová, Eva (BU-J) ORCID
Vosátka, Miroslav (BU-J) ORCID
Hajšlová, J. (CZ)
Kaštánek, P. (CZ)
Viktorová, J. (CZ)
Ruml, T. (CZ)Article number 403 Source Title Antibiotics (Basel). - : MDPI - ISSN 2079-6382
Roč. 9, č. 7 (2020), s. 1-20Number of pages 20 s. Language eng - English Country CH - Switzerland Keywords biofilm ; dental plaque ; quorum sensing ; microbial resistance Subject RIV CC - Organic Chemistry OECD category Organic chemistry Method of publishing Open access Institutional support BU-J - RVO:67985939 UT WOS 000557172400001 EID SCOPUS 85087806912 DOI 10.3390/antibiotics9070403 Annotation The publication reported on the chemical composition and the antibiofilm activity of 15 methanolic extracts of Iris species against both mono-(Pseudomonas aeruginosa, Staphylococcus aureus) and multi-species oral biofilms (Streptococcus gordonii, Veillonella parvula, Fusobacterium nucleatum subsp. nucleatum, and Actinomyces naeslundii). The phytochemical profiles of Iris pallida s.l., Iris versicolor L., Iris lactea Pall., Iris carthaliniae Fomin, and Iris germanica were determined by ultra-high performance liquid chromatography-high-resolution tandem mass spectroscopy (UHPLC-HRMS/MS) analysis, and a total of 180 compounds were identified among Iris species with (iso)flavonoid dominancy. I. pallida, I. versicolor, and I. germanica inhibited both the quorum sensing and adhesion during biofilm formation in a concentration-dependent manner. However, the extracts were less active against maturated biofilms. Of the five tested species, Iris pallida s.l. was the most effective at both inhibiting biofilm formation and disrupting existing biofilms, and the leaf extract exhibited the strongest inhibitory effect compared to the root and rhizome extracts. The cytotoxicity of the extracts was excluded in human fibroblasts. The inhibition of bacterial adhesion significantly correlated with myristic acid content, and quorum sensing inhibition correlated with the 7-β-hydroxystigmast-4-en-3-one content. These findings could be useful for establishing an effective tool for the control of oral biofilms and thus dental diseases. Workplace Institute of Botany Contact Martina Bartošová, martina.bartosova@ibot.cas.cz, ibot@ibot.cas.cz, Tel.: 271 015 242 ; Marie Jakšová, marie.jaksova@ibot.cas.cz, Tel.: 384 721 156-8 Year of Publishing 2021 Electronic address https://doi.org/10.3390/antibiotics9070403
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