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治療に使用するための、置換ヘテロペンタジエノ－ピロロピリミジンリボヌクレオシド
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SYSNO ASEP 0532881 Document Type P - Patent R&D Document Type Patent or other outcome protected by special legislation Title 治療に使用するための、置換ヘテロペンタジエノ－ピロロピリミジンリボヌクレオシド Title Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides for therapeutic use Author(s) Hocek, Michal (UOCHB-X) RID, ORCID
Tokarenko, Anna (UOCHB-X)
Smolen, Sabina (UOCHB-X)
Hajdúch, M. (CZ)
Džubák, P. (CZ)Year of issue 2020 Possible third party use of the result A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence Royalty requested A - Poskytovatel licence požaduje licenční poplatek Patent no. or utility model no. or industrial design no. JP6685475 Date of the patent acceptance 22.04.2020 Name of the patent owner Ústav organické chemie a biochemie AV ČR, v. v. i. - Univerzita Palackého v Olomouci Code of the issuer name JP001 - Japan Patent Office (JPO) Tokyo Current use A - Pouze udělený (dosud nevyužívaný) patent nebo patent využívaný jeho vlastníkem Language jpn - Japanese Keywords nucleosides ; cytostatics ; deazapurines Subject RIV CC - Organic Chemistry OECD category Medicinal chemistry R&D Projects GA16-00178S GA ČR - Czech Science Foundation (CSF) TE01020028 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) Institutional support UOCHB-X - RVO:61388963 Annotation 般式Ｉにて示される置換ヘテロペンタジエノ−ピロロピリミジンリボヌクレオシド、当該置換ヘテロペンタジエノ−ピロロピリミジンリボヌクレオシドの薬学的に許容可能な塩、当該置換ヘテロペンタジエノ−ピロロピリミジンリボヌクレオシドの光学異性体、および、当該光学異性体の混合物であって、一般式Ｉ中、Ｒは、フラン−２−イル、フラン−３−イル、ベンゾフラン−２−イル、メチルスルファニル、メトキシ、アミノ、ジメチルアミノ、メチル、および、クロロを含む群から選択される。本発明に係る化合物は、多様な組織由来の腫瘍を含む幅広い多様な疾患における細胞株に対して、強い細胞増殖抑制活性および細胞毒性活性を示す。 Description in English Substituted heteropentadieno-pyrrolopyrimidine ribonucleosides of general formula (I), where R is selected from the group comprising furan-2-yl, furan-3-yl, benzofuran-2-yl, methylsulfanyl, methoxy, amino, dimethylamino, methyl or chloro, and pharmaceutically acceptable salt thereof, their optical isomers and mixtures of such optical isomers. Compounds according to the invention show strong cytostatic and cytotoxic effects on cell lines in a wide variety of diseases including tumors of various histogenic origin. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2021 Electronic address https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=JP&NR=6685475B2&KC=B2&FT=D&ND=4&date=20200422&DB=&locale=en_EP
Number of the records: 1