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The ε-Al.sub.x./sub.Fe.sub.2-x./sub.O.sub.3./sub. nanomagnets as MRI contrast agents: Factors influencing transverse relaxivity
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SYSNO ASEP 0532457 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The ε-AlxFe2-xO3 nanomagnets as MRI contrast agents: Factors influencing transverse relaxivity Author(s) Kubíčková, Lenka (FZU-D) ORCID
Kaman, Ondřej (FZU-D) RID, ORCID
Veverka, Pavel (FZU-D) RID, ORCID
Herynek, V. (CZ)
Brázda, Petr (FZU-D) RID, ORCID
Vosmanská, M. (CZ)
Kmječ, T. (CZ)
Dvořák, P. (CZ)
Kubániová, D. (CZ)
Kohout, J. (CZ)Number of authors 10 Article number 124423 Source Title Colloids and Surfaces A-Physicochemical and Engineering Aspects. - : Elsevier - ISSN 0927-7757
Roč. 589, Feb (2020), s. 1-11Number of pages 11 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords epsilon polymorph iron oxide ; magnetic nanoparticles ; core-shell nanoparticles ; Mössbauer spectroscopy ; relaxometry ; magnetic resonance imaging Subject RIV BM - Solid Matter Physics ; Magnetism OECD category Condensed matter physics (including formerly solid state physics, supercond.) R&D Projects GA19-02584S GA ČR - Czech Science Foundation (CSF) EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support FZU-D - RVO:68378271 UT WOS 000513861400023 EID SCOPUS 85077507452 DOI 10.1016/j.colsurfa.2020.124423 Annotation Novel type of contrast agents based on non-superparamagnetic nanoparticles of aluminum-doped epsilon polymorph of Fe2O3 is suggested and used as a model system to elucidate the role of magnetic blocking and other factors in the transverse relaxation of water. Specifically, the dependence of the transverse relaxivity r2 on the magnetic field, temperature, magnetization, surface modification and thickness of silica coating is analyzed for the epsilon-AlxFe2-xO3 nanoparticles with x = 0.23 and the median size of 21 nm. Irreversible magnetization processes in aqueous suspension of coated clusters of magnetic crystallites resulted in the field dependence of r2. The temperature dependence of r2 was interpreted by the combination of two different regimes - motional averaging and static dephasing regimes. Moreover, the performance of the contrast agent was demonstrated not only in ultra-high-field MRI at 11.75 T but also by imaging in vivo on a mouse model at 1 T. Workplace Institute of Physics Contact Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579 Year of Publishing 2021 Electronic address https://doi.org/10.1016/j.colsurfa.2020.124423
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