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Fluorinated water-soluble poly(2-oxazoline)s as highly sensitive 19F MRI contrast agents
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SYSNO ASEP 0531986 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Fluorinated water-soluble poly(2-oxazoline)s as highly sensitive 19F MRI contrast agents Author(s) Sedlacek, O. (BE)
Jirák, D. (CZ)
Vít, M. (CZ)
Ziolkowska, N. (CZ)
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Hoogenboom, R. (BE)Source Title Macromolecules. - : American Chemical Society - ISSN 0024-9297
Roč. 53, č. 15 (2020), s. 6387-6395Number of pages 9 s. Language eng - English Country US - United States Keywords imaging agents ; magnetic resonance imaging ; fluorine Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000562138100026 EID SCOPUS 85089864418 DOI 10.1021/acs.macromol.0c01228 Annotation Recently, 19F magnetic resonance imaging (MRI) emerged as a powerful noninvasive diagnostic tool in modern medicine. Fluorinated polymer materials represent an attractive class of MRI contrast agents (CAs) due to their structural variability and tunable properties. Herein, we describe for the first time the 19F MRI of CAs based on fluorinated water-soluble poly(2-oxazoline)s (PAOx), a polymer class with increasing popularity in biomedical sciences. A series of fluorinated PAOx with increasing fluorine content were synthesized by controlled side-chain hydrolysis of poly(2-methyl-2-oxazoline) followed by reacylation of its ethylenimine units by difluoroacetic anhydride. As the increasing fluorine content leads to the copolymer hydrophobization, their composition was optimized for maximal 19F MRI performance while retaining good solubility in water. The magnetic properties of the water-soluble polymers were studied in vitro by 19F NMR and MRI, revealing their outstanding relaxation properties and imaging sensitivity. All CAs were found to be noncytotoxic for HeLa cells in vitro. Finally, the diagnostic potential of the new CAs was demonstrated by a successful in vivo19F MRI visualization of the selected fluorinated polymer in rats. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://pubs.acs.org/doi/10.1021/acs.macromol.0c01228
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