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Implant-forming polymeric 19F MRI-tracer with tunable dissolution

SYSNO ASEP	0531585
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Implant-forming polymeric 19F MRI-tracer with tunable dissolution
Author(s)	Kolouchová, Kristýna (UMCH-V)_{ORCID, RID} Jirák, D. (CZ) Groborz, Ondřej (UMCH-V)_{ORCID, RID} Sedlacek, O. (BE) Ziolkowska, N. (CZ) Vít, M. (CZ) Sticová, E. (CZ) Gálisová, A. (CZ) Švec, Pavel (UMCH-V)_{RID, ORCID} Trousil, Jiří (UMCH-V)_{RID, ORCID} Hajek, M. (CZ) Hrubý, Martin (UMCH-V)_{RID, ORCID}
Source Title	Journal of Controlled Release. - : Elsevier - ISSN 0168-3659 Roč. 327, 10 November (2020), s. 50-60
Number of pages	11 s.
Language	eng - English
Country	NL - Netherlands
Keywords	polymer implant ; 19F magnetic resonance imaging ; double-stimuli responsivity
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	LTC19032 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA18-07983S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013
UT WOS	000585933700006
EID SCOPUS	85089267901
DOI	10.1016/j.jconrel.2020.07.026
Annotation	Magnetic resonance imaging (MRI) using 19F-based tracers has emerged as a promising multi-purpose noninvasive diagnostic tool and its application requires the use of various 19F-based tracers for the intended diagnostic purpose. In this study, we report a series of double-stimuli-responsive polymers for use as injectable implants, which were designed to form implants under physiological conditions, and to subsequently dissolve with different dissolution rates (t1/2 ranges from 30 to more than 250 days). Our polymers contain a high concentration of fluorine atoms, providing remarkable signal detectability, and both a hydrophilic monomer and a pH-responsive monomer that alter the biodistribution properties of the implant. The implant location and dissolution were observed using 19F MRI, which allows the anatomic extent of the implant to be monitored. The dissolution kinetics and biocompatibility of these materials were thoroughly analyzed. No sign of toxicity in vitro or in vivo or pathology in vivo was observed, even in chronic administration. The clinical applicability of our polymers was further confirmed via imaging of a rat model by employing an instrument currently used in human medicine.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2021
Electronic address	https://www.sciencedirect.com/science/article/pii/S0168365920304107?via%3Dihub

Number of the records: 1