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Can Maternal Autoantibodies Play an Etiological Role in ASD Development?

SYSNO ASEP	0531281
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Can Maternal Autoantibodies Play an Etiological Role in ASD Development?
Author(s)	Dudová, I. (CZ) Horáčková, K. (CZ) Hrdlička, M. (CZ) Balaštík, Martin (FGU-C)_{RID, ORCID}
Source Title	Neuropsychiatric Disease and Treatment . - : Dove Medical Press Roč. 16, Jun (2020), s. 1391-1398
Number of pages	8 s.
Language	eng - English
Country	NZ - New Zealand
Keywords	maternal autoantibodies ; autism spectrum disorder ; animal models ; CRMP2 ; therapy
Subject RIV	FH - Neurology
OECD category	Clinical neurology
R&D Projects	NV18-04-00085 GA MZd - Ministry of Health (MZ)
Method of publishing	Open access
Institutional support	FGU-C - RVO:67985823
UT WOS	000537737600001
EID SCOPUS	85085978936
DOI	10.2147/NDT.S239504
Annotation	Autism spectrum disorder (ASD) is a heterogeneous condition with multiple etiologies and risk factors - both genetic and environmental. Recent data demonstrate that the immune system plays an important role in prenatal brain development. Deregulation of the immune system during embryonic development can lead to neurodevelopmental changes resulting in ASD. One of the potential etiologic factors in the development of ASD has been identified as the presence of maternal autoantibodies targeting fetal brain proteins. The type of ASD associated with the presence of maternal autoantibodies has been referred to as maternal antibodies related to ASD (MAR ASD). The link between maternal autoantibodies and ASD has been demonstrated in both clinical studies and animal models, but the exact mechanism of their action in the pathogenesis of ASD has not been clarified yet. Several protein targets of ASD-related maternal autoantibodies have been identified. Here, we discuss the role of microtubule-associated proteins of the collapsin response mediator protein (CRMP) family in neurodevelopment and ASD. CRMPs have been shown to integrate multiple signaling cascades regulating neuron growth, guidance or migration. Their targeting by maternal autoantibodies could change CRMP levels or distribution in the developing nervous system, leading to defects in axon growth/guidance, cortical migration, or dendritic projection, which could play an etiological role in ASD development. In addition, we discuss the future possibilities of MAR ASD treatment.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2021
Electronic address	https://www.dovepress.com/can-maternal-autoantibodies-play-an-etiological-role-in-asd-developmen-peer-reviewed-article-NDT

Number of the records: 1