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Cationic Emulsion-Based Artificial Tears as a Mimic of Functional Healthy Tear Film for Restoration of Ocular Surface Homeostasis in Dry Eye Disease
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SYSNO ASEP 0531108 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Cationic Emulsion-Based Artificial Tears as a Mimic of Functional Healthy Tear Film for Restoration of Ocular Surface Homeostasis in Dry Eye Disease Author(s) Daull, P. (FR)
Amrane, M. (FR)
Ismail, D. (FR)
Georgiev, G. (BG)
Cwiklik, Lukasz (UFCH-W) RID, ORCID
Baudouin, Ch. (FR)
Leonardi, A. (IT)
Garhofer, G. (AT)
Garrigue, J.-S. (FR)Source Title Journal of Ocular Pharmacology and Therapeutics. - : Mary Ann Liebert - ISSN 1080-7683
Roč. 36, č. 6 (2020), s. 355-365Number of pages 11 s. Language eng - English Country US - United States Keywords dry eye ; tear film lipid layer ; artificial tear Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry Method of publishing Open access Institutional support UFCH-W - RVO:61388955 UT WOS 000538187600001 EID SCOPUS 85088845603 DOI 10.1089/jop.2020.0011 Annotation Dry eye disease (DED) is a complex multifactorial disease that affects an increasing number of patients worldwide. Close to 30% of the population has experienced dry eye (DE) symptoms and presented with some signs of the disease during their lifetime. The significant heterogeneity in the medical background of patients with DEs and in their sensitivity to symptoms renders a clear understanding of DED complicated. It has become evident over the past few years that DED results from an impairment of the ocular surface homeostasis. Hence, a holistic treatment approach that concomitantly addresses the different mechanisms that result in the destabilization of the tear film (TF) and the ocular surface would be appropriate. The goal of the present review is to compile the different types of scientific evidence (from in silico modeling to clinical trials) that help explain the mechanism of action of cationic emulsion (CE)-based eye drop technology for the treatment of both the signs and the symptoms of DED. These CE-based artificial tear (AT) eye drops designed to mimic, from a functional point of view, a healthy TF contribute to the restoration of a healthy ocular surface environment and TF that leads to a better management of DE patients. The CE-based AT eye drops help restore the ocular surface homeostasis in patients who have unstable TF or no tears. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2021 Electronic address http://hdl.handle.net/11104/0309845
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