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Obesity-Induced Changes in Bone Marrow Homeostasis

SYSNO ASEP	0531064
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Obesity-Induced Changes in Bone Marrow Homeostasis
Author(s)	Beňová, Andrea (FGU-C)_ORCID Tencerová, Michaela (FGU-C)_{RID, ORCID}
Article number	294
Source Title	Frontiers in Endocrinology. - : Frontiers Media - ISSN 1664-2392 Roč. 11, May 12 (2020)
Number of pages	15 s.
Language	eng - English
Country	CH - Switzerland
Keywords	bone marrow microenvironment ; bone marrow mesenchymal stem cells ; hematopoietic stem cells ; immune responses ; obesity ; life-style interventions
Subject RIV	EA - Cell Biology
OECD category	Cell biology
R&D Projects	GA20-03586S GA ČR - Czech Science Foundation (CSF)
Method of publishing	Open access
Institutional support	FGU-C - RVO:67985823
UT WOS	000537214700001
EID SCOPUS	85086522610
DOI	10.3389/fendo.2020.00294
Annotation	Obesity is characterized by low-grade inflammation, which is accompanied by increased accumulation of immune cells in peripheral tissues including adipose tissue (AT), skeletal muscle, liver and pancreas, thereby impairing their primary metabolic functions in the regulation of glucose homeostasis. Obesity has also shown to have a detrimental effect on bone homeostasis by altering bone marrow and hematopoietic stem cell differentiation and thus impairing bone integrity and immune cell properties. The origin of immune cells arises in the bone marrow, which has been shown to be affected with the obesogenic condition via increased cellularity and shifting differentiation and function of hematopoietic and bone marrow mesenchymal stem cells in favor of myeloid progenitors and increased bone marrow adiposity. These obesity-induced changes in the bone marrow microenvironment lead to dramatic bone marrow remodeling and compromising immune cell functions, which in turn affect systemic inflammatory conditions and regulation of whole-body metabolism. However, there is limited information on the inflammatory secretory factors creating the bone marrow microenvironment and how these factors changed during metabolic complications. This review summarizes recent findings on inflammatory and cellular changes in the bone marrow in relation to obesity and further discuss whether dietary intervention or physical activity may have beneficial effects on the bone marrow microenvironment and whole-body metabolism.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2021
Electronic address	https://www.frontiersin.org/articles/10.3389/fendo.2020.00294/full

Number of the records: 1