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.gamma.-Butyrolactone copolymerization with the well-documented polymer drug carrier poly(ethylene oxide)-block-poly(.epsilon.-caprolactone) to fine-tune its biorelevant properties

SYSNO ASEP	0524226
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	.gamma.-Butyrolactone copolymerization with the well-documented polymer drug carrier poly(ethylene oxide)-block-poly(.epsilon.-caprolactone) to fine-tune its biorelevant properties
Author(s)	Urbánek, Tomáš (UMCH-V)_{ORCID, RID} Trousil, Jiří (UMCH-V)_{RID, ORCID} Rak, D. (SK) Gunár, Kristýna (UMCH-V)_{RID, ORCID} Konefal, Rafal (UMCH-V)_{RID, ORCID} Šlouf, Miroslav (UMCH-V)_{RID, ORCID} Sedlák, M. (SK) Šebestová Janoušková, Olga (UMCH-V)_RID Hrubý, Martin (UMCH-V)_{RID, ORCID}
Article number	1900408
Source Title	Macromolecular Bioscience. - : Wiley - ISSN 1616-5187 Roč. 20, č. 5 (2020), s. 1-15
Number of pages	15 s.
Language	eng - English
Country	DE - Germany
Keywords	biodegradation ; macrophages ; nanomedicine
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	GA17-07164S GA ČR - Czech Science Foundation (CSF)
	GA17-09998S GA ČR - Czech Science Foundation (CSF)
	LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013
UT WOS	000533401200005
EID SCOPUS	85081717550
DOI	10.1002/mabi.201900408
Annotation	Polymeric drug carriers exhibit excellent properties that advance drug delivery systems. In particular, carriers based on poly(ethylene oxide)‐block‐poly(ε‐caprolactone) are very useful in pharmacokinetics. In addition to their proven biocompatibility, there are several requirements for the efficacy of the polymeric drug carriers after internalization, e.g., nanoparticle behavior, cellular uptake, the rate of degradation, and cellular localization. The introduction of γ‐butyrolactone units into the hydrophobic block enables the tuning of the abovementioned properties over a wide range. In this study, a relatively high content of γ‐butyrolactone units with a reasonable yield of ≈60% is achieved by anionic ring‐opening copolymerization using 1,5,7‐triazabicyclo[4.4.0]dec‐5‐ene as a very efficient catalyst in the nonpolar environment of toluene with an incorporated γ‐butyrolactone content of ≈30%. The content of γ‐butyrolactone units can be easily modulated according to the feed ratio of the monomers. This method enables control over the rate of degradation so that when the content of γ‐butyrolactone increases, the rate of degradation increases. These findings broaden the application possibilities of polyester‐polyether‐based nanoparticles for biomedical applications, such as drug delivery systems.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2021
Electronic address	https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201900408

Number of the records: 1