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Interleaflet Coupling of Lipid Nanodomains – Insights From in vitro Systems
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SYSNO ASEP 0524199 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Interleaflet Coupling of Lipid Nanodomains – Insights From in vitro Systems Author(s) Sarmento, Maria Joäo (UFCH-W) ORCID, RID
Hof, Martin (UFCH-W) RID, ORCID
Šachl, Radek (UFCH-W) RID, ORCIDArticle number 284 Source Title Frontiers in Cell and Developmental Biology. - : Frontiers Research Foundation - ISSN 2296-634X
Roč. 8, APR 2020 (2020)Number of pages 16 s. Language eng - English Country CH - Switzerland Keywords domain registration ; interleaftet coupling ; membrane asymmetry Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry R&D Projects GX19-26854X GA ČR - Czech Science Foundation (CSF) GA18-04871S GA ČR - Czech Science Foundation (CSF) EF16_027/0008355 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UFCH-W - RVO:61388955 UT WOS 000533366400001 EID SCOPUS 85084520337 DOI 10.3389/fcell.2020.00284 Annotation The plasma membrane is a complex system, consisting of two layers of lipids and proteins compartmentalized into small structures called nanodomains. Despite the asymmetric composition of both leaflets, coupling between the layers is surprisingly strong. This can be evidenced, for example, by recent experimental studies performed on phospholipid giant unilamellar vesicles showing that nanodomains formed in the outer layer are perfectly registered with those in the inner leaflet. Similarly, microscopic phase separation in one leaflet can induce phase separation in the opposing leaflet that would otherwise be homogeneous. In this review, we summarize the current theoretical and experimental knowledge that led to the current view that domains are – irrespective of their size – commonly registered across the bilayer. Mechanisms inducing registration of nanodomains suggested by theory and calculations are discussed. Furthermore, domain coupling is evidenced by experimental studies based on the sparse number of methods that can resolve registered from independent nanodomains. Finally, implications that those findings using model membrane studies might have for cellular membranes are discussed. Workplace J. Heyrovsky Institute of Physical Chemistry Contact Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196 Year of Publishing 2021 Electronic address http://hdl.handle.net/11104/0308581
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