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Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women
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SYSNO ASEP 0524170 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Exercise training induces insulin-sensitizing PAHSAs in adipose tissue of elderly women Author(s) Březinová, Marie (FGU-C) ORCID
Čajka, Tomáš (FGU-C) RID, ORCID, SAI
Oseeva, Marina (FGU-C) ORCID, RID
Štěpán, M. (CZ)
Daďová, K. (CZ)
Rossmeislová, L. (CZ)
Matouš, M. (CZ)
Šiklová, M. (CZ)
Rossmeisl, Martin (FGU-C) RID, ORCID
Kuda, Ondřej (FGU-C) RID, ORCID, SAIArticle number 158576 Source Title Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. - : Elsevier - ISSN 1388-1981
Roč. 1865, č. 2 (2020)Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords lipidomics ; mass spectrometry ; exercise ; omega-3 fatty acids ; adipose tissue ; PAHSA ; FAHFA ; lipokine ; elderly women ; ether lipids ; FAHFA-TG Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition OECD category Endocrinology and metabolism (including diabetes, hormones) R&D Projects NV16-29182A GA MZd - Ministry of Health (MZ) LTAUSA17173 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GJ17-10088Y GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000509816500022 EID SCOPUS 85075263746 DOI 10.1016/j.bbalip.2019.158576 Annotation Adverse effects of aging can be delayed with life-style interventions. We examined how exercise training (ET) alone or combined with omega-3 polyunsaturated fatty acid (PUFA) affects serum and adipose tissue (AT) lipidome in older women. Fifty-five sedentary older women were included in the physical activity program and given either sunflower (Placebo) or wax esters-rich (Calanus) oil capsules for 4 months. Serum and subcutaneous abdominal AT samples were acquired while maximum rates of oxygen consumption (VO2 max), insulin sensitivity (hyperinsulinemic-euglycemic clamps) and comprehensive lipidome profiles were determined before and after the study. ET increased VO2 max in both groups. Lipidomics profiling revealed unusual serum triacylglycerols and phospholipids with ether-bound alkyls in the Calanus group, while ET generally induced shorter-chain triacylglycerols in AT, suggesting increased de novo lipogenesis. The latter was positively associated with whole-body insulin sensitivity. Unexpectedly, insulin-sensitizing lipokines from the family of branched palmitic acid esters of hydroxy stearic acid (PAHSAs) were elevated in both serum and AT after ET, while PAHSAs-containing triacylglycerols were detected in AT. ET stimulated beneficial changes in AT, including PAHSAs synthesis. Although the added value of omega-3 PUFA supplementation was not proven, our discovery can help understand the nature of the metabolic benefits of exercise. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://doi.org/10.1016/j.bbalip.2019.158576
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