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Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines
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SYSNO ASEP 0523785 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines Author(s) Dinku, W. (ET)
Isaksson, J. (NO)
Rylandsholm, F. G. (NO)
Bouř, Petr (UOCHB-X) RID, ORCID
Brichtová, Eva (UOCHB-X) ORCID
Choi, S. U. (KR)
Lee, S. H. (KR)
Jung, Y. S. (KR)
No, Z. S. (ET)
Svendsen, J. S. M. (NO)
Aasen, A. J. (NO)
Dekebo, A. (ET)Article number 16 Source Title Applied Biological Chemistry. - : Springer - ISSN 2468-0834
Roč. 63, č. 1 (2020)Number of pages 11 s. Language eng - English Country SG - Singapore Keywords Commiphora africana ; Commafric A ; anti-proliferative ; SRB ; A549 cell line Subject RIV BO - Biophysics OECD category Biophysics R&D Projects GA18-05770S GA ČR - Czech Science Foundation (CSF) LTC17012 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UOCHB-X - RVO:61388963 UT WOS 000520375700001 EID SCOPUS 85081992655 DOI 10.1186/s13765-020-00499-w Annotation Myrrh, a resin derived from the damaged bark of Commiphora genus, has traditionally been used for treatment of various human diseases, such as amenorrhea, ache, tumors, fever, and stomach pains. In spite of this widespread use of the myrrh in Ethiopia, the pharmacological activity and chemical composition have not been studied in detail. A new tricyclic triterpene acid (3S,4S,14S,7E,17E,21Z)-3,30-dihydroxypodioda-7,17,21-trien-4-carboxylic acid (commafric A) has been isolated from a crude methanolic extract of Commiphora africana (A. Rich.) Engl. resin along with the known pentacyclic triterpene alpha-amyrin. The structure of commafric A was characterized using different spectroscopic techniques such as 1D and 2D NMR, IR, and VCD combined with computations. The anti-proliferative activity of both isolated compounds was evaluated using SRB based colorimetric cellular assay against four human cancer cell lines. Etoposide was used as a positive control. Commafric A showed significant anti-proliferative effects against non-small cell lung cancer (A549) with IC50 values of 4.52 mu g/ml. The pentacyclic triterpene alpha-amyrin showed a weak anti-proliferative activity against A2780 (ovarian cancer), MIA-PaCa-2 (pancreatic cancer), and SNU638 (stomach cancer) cell lines tested with IC50 values ranging 9.28 to 28.22 mu g/ml. Commafric A possessed anti-proliferative activity against non-small cell lung cancer (A549), which suggests that commafric A has potential to be further optimized being a lead compound in the search for new drugs against cancer diseases. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2021 Electronic address https://applbiolchem.springeropen.com/articles/10.1186/s13765-020-00499-w
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