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Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system
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SYSNO ASEP 0523096 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve SCOPUS Title Primary sensory map formations reflect unique needs and molecular cues specific to each sensory system Author(s) Fritzsch, B. (US)
Elliott, K. L. (US)
Pavlínková, Gabriela (BTO-N) RID, ORCIDNumber of authors 3 Source Title F1000Research. - : F1000Research - ISSN 2046-1402
Roč. 8, č. 2019 (2019)Number of pages 15 s. Language eng - English Country GB - United Kingdom Keywords Cochleotopic map ; Olfactory map ; Primary sensory maps ; Retinotopic map ; Taste map ; Vestibular map Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA17-04719S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support BTO-N - RVO:86652036 EID SCOPUS 85064852682 DOI 10.12688/f1000research.17717.1 Annotation Interaction with the world around us requires extracting meaningful signals to guide behavior. Each of the six mammalian senses (olfaction, vision, somatosensation, hearing, balance, and taste) has a unique primary map that extracts sense-specific information. Sensory systems in the periphery and their target neurons in the central nervous system develop independently and must develop specific connections for proper sensory processing. In addition, the regulation of sensory map formation is independent of and prior to central target neuronal development in several maps. This review provides an overview of the current level of understanding of primary map formation of the six mammalian senses. Cell cycle exit, combined with incompletely understood molecules and their regulation, provides chemoaffinity-mediated primary maps that are further refined by activity. The interplay between cell cycle exit, molecular guidance, and activity-mediated refinement is the basis of dominance stripes after redundant organ transplantations in the visual and balance system. A more advanced level of understanding of primary map formation could benefit ongoing restoration attempts of impaired senses by guiding proper functional connection formations of restored sensory organs with their central nervous system targets. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2020 Electronic address https://f1000research.com/articles/8-345/v1
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