Number of the records: 1
Nuclear Phosphoinositides and Phase Separation: Important Players in Nuclear Compartmentalization
- 1.
SYSNO ASEP 0523064 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Ostatní články Title Nuclear Phosphoinositides and Phase Separation: Important Players in Nuclear Compartmentalization Author(s) Sztacho, Martin (UMG-J) ORCID
Sobol, Margaryta (UMG-J) RID
Balaban, Can (UMG-J)
Escudeiro Lopes, Sara Eliana (UMG-J) ORCID
Hozák, Pavel (UMG-J) RID, ORCIDSource Title Advances in Biological Regulation. - : Elsevier - ISSN 2212-4926
Roč. 71, January (2019), s. 111-117Number of pages 7 s. Publication form Online - E Language eng - English Country NL - Netherlands Keywords Nuclear architecture ; Nucleus ; Phase separation ; Phosphoinositides ; Transcription Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology R&D Projects GA16-03346S GA ČR - Czech Science Foundation (CSF) GA17-09103S GA ČR - Czech Science Foundation (CSF) TE01020118 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LM2015062 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LO1419 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Limited access Institutional support UMG-J - RVO:68378050 DOI 10.1016/j.jbior.2018.09.009 Annotation Nuclear phosphoinositides are recognized as regulators of many nuclear processes including chromatin remodeling, splicing, transcription, DNA repair and epigenetics. These processes are spatially organized in different nuclear compartments. Phase separation is involved in the formation of various nuclear compartments and molecular condensates separated from surrounding environment. The surface of such structures spatiotemporally coordinates formation of protein complexes. PI(4,5)P2 (PIP2) integration into phase-separated structures might provide an additional step in their spatial diversification by attracting certain proteins with affinity to PIP2. Our laboratory has recently identified novel membrane-free PIP2-containing structures, so called Nuclear Lipid Islets (NLIs). We provide an evidence that these structures are evolutionary conserved in different organisms. We hypothesize that NLIs serve as a scaffolding platform which facilitates the formation of transcription factories, thus participating in the formation of nuclear architecture competent for transcription. In this review we speculate on a possible role of NLIs in the integration of various processes linked to RNAPII transcription, chromatin remodeling, actin-myosin interaction, alternative splicing and lamin structures. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2020 Electronic address https://www.sciencedirect.com/science/article/abs/pii/S2212492618301313?via%3Dihub
Number of the records: 1