Number of the records: 1
Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties
- 1.
SYSNO ASEP 0522842 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties Author(s) Braunová, Alena (UMCH-V) RID
Chytil, Petr (UMCH-V) RID, ORCID
Laga, Richard (UMCH-V) RID, ORCID
Šírová, Milada (MBU-M) RID, ORCID
Machová, Daniela (UMCH-V)
Parnica, Jozef (UMCH-V)
Říhová, Blanka (MBU-M) RID
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Etrych, Tomáš (UMCH-V) RID, ORCIDSource Title Journal of Controlled Release. - : Elsevier - ISSN 0168-3659
Roč. 321, 10 May (2020), s. 718-733Number of pages 16 s. Language eng - English Country NL - Netherlands Keywords polymer micelles ; drug delivery ; EPR effect Subject RIV CD - Macromolecular Chemistry OECD category Polymer science Subject RIV - cooperation Institute of Microbiology - Microbiology, Virology R&D Projects NV16-28600A GA MZd - Ministry of Health (MZ) GA17-13283S GA ČR - Czech Science Foundation (CSF) GA17-08084S GA ČR - Czech Science Foundation (CSF) LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LTAUSA18083 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GA19-01417S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 ; MBU-M - RVO:61388971 UT WOS 000526179100049 EID SCOPUS 85080982059 DOI 10.1016/j.jconrel.2020.03.002 Annotation The study compared the physico-chemical and biological properties of a water-soluble star-like polymer nanomedicine with three micellar nanomedicines formed by self-assembly of amphiphilic copolymers differing in their hydrophobic part (statistical, block and thermosensitive block copolymers). All nanomedicines showed a pH-responsive release of the drug, independent on polymer structure. Significant penetration of all polymer nanomedicines into tumor cells in vitro was demonstrated, where the most pronounced effect was observed for statistical- or diblock copolymer-based micellar systems. Tumor accumulation in vivo was dependent on the stability of the nanomedicines in solution, being the highest for the star-like system, followed by the most stable micellar nanomedicines. The star-like polymer nanomedicine showed a superior therapeutic effect. Since the micellar systems exhibited slightly lower systemic toxicity, they may exhibit the same efficacy as the star-like soluble system when administered at equitoxic doses. In conclusion, treatment efficacy of studied nanomedicines was directly controlled by the drug pharmacokinetics, namely by their ability to circulate in the bloodstream for the time needed for effective accumulation in the tumor due to the enhanced permeability and retention (EPR) effect. Easy and scalable synthesis together with the direct reconstitution possibility for nanomedicine application made these nanomedicines excellent candidates for further clinical evaluation. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S0168365920301413?via%3Dihub
Number of the records: 1