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Antitubercular nanocarrier monotherapy: study of in vivo efficacy and pharmacokinetics for rifampicin

SYSNO ASEP	0522432
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Antitubercular nanocarrier monotherapy: study of in vivo efficacy and pharmacokinetics for rifampicin
Author(s)	Trousil, Jiří (UMCH-V)_{RID, ORCID} Pavliš, O. (CZ) Kubíčková, P. (CZ) Škorič, M. (CZ) Marešová, V. (CZ) Pavlova, Ewa (UMCH-V)_RID Knudsen, K. D. (NO) Dai, Y.-S. (TW) Zimmerman, M. (US) Dartois, V. (US) Fang, J.-Y. (TW) Hrubý, Martin (UMCH-V)_{RID, ORCID}
Source Title	Journal of Controlled Release. - : Elsevier - ISSN 0168-3659 Roč. 321, 10 May (2020), s. 312-323
Number of pages	12 s.
Language	eng - English
Country	NL - Netherlands
Keywords	tuberculosis ; nanoparticles ; drug delivery system
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	GA17-07164S GA ČR - Czech Science Foundation (CSF)
	GA17-09998S GA ČR - Czech Science Foundation (CSF)
	LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013
UT WOS	000526179100022
EID SCOPUS	85079633432
DOI	10.1016/j.jconrel.2020.02.026
Annotation	Tuberculosis represents a major global health problem for which improved approaches are needed to shorten the course of treatment and to combat the emergence of resistant strains. The development of effective and safe nanobead-based interventions can be particularly relevant for increasing the concentrations of antitubercular agents within the infected site and reducing the concentrations in the general circulation, thereby avoiding off-target toxic effects. In this work, rifampicin, a first-line antitubercular agent, was encapsulated into biocompatible and biodegradable polyester-based nanoparticles. In a well-established BALB/c mouse model of pulmonary tuberculosis, the nanoparticles provided improved pharmacokinetics and pharmacodynamics. The nanoparticles were well tolerated and much more efficient than an equivalent amount of free rifampicin.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2021
Electronic address	https://www.sciencedirect.com/science/article/pii/S0168365920301164?via%3Dihub

Number of the records: 1