HPMA-based star polymer biomaterials with tuneable structure and biodegradability tailored for advanced drug delivery to solid tumours

Kostka, Libor; Kotrchová, Lenka; Šubr, Vladimír; Libánská, Alena; Ferreira, C. A.; Malátová, Iva; Lee, H. J.; Barnhart, T. E.; Engle, J. W.; Cai, W.; Šírová, Milada; Etrych, Tomáš

doi:https://dx.doi.org/10.1016/j.biomaterials.2019.119728

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HPMA-based star polymer biomaterials with tuneable structure and biodegradability tailored for advanced drug delivery to solid tumours

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SYSNO ASEP	0521948
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	HPMA-based star polymer biomaterials with tuneable structure and biodegradability tailored for advanced drug delivery to solid tumours
Author(s)	Kostka, Libor (UMCH-V)_{RID, ORCID} Kotrchová, Lenka (UMCH-V)_{RID, ORCID} Šubr, Vladimír (UMCH-V)_{RID, ORCID} Libánská, Alena (UMCH-V)_{RID, ORCID} Ferreira, C. A. (US) Malátová, Iva (MBU-M) Lee, H. J. (US) Barnhart, T. E. (US) Engle, J. W. (US) Cai, W. (US) Šírová, Milada (MBU-M)_{RID, ORCID} Etrych, Tomáš (UMCH-V)_{RID, ORCID}
Article number	119728
Source Title	Biomaterials. - : Elsevier - ISSN 0142-9612 Roč. 235, March (2020), s. 1-14
Number of pages	14 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	HPMA ; star-like polymers ; drug delivery
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
Subject RIV - cooperation	Institute of Microbiology - Microbiology, Virology
R&D Projects	LTAUSA18083 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA17-13283S GA ČR - Czech Science Foundation (CSF)
	GA19-05649S GA ČR - Czech Science Foundation (CSF)
	NV16-28600A GA MZd - Ministry of Health (MZ)
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013 ; MBU-M - RVO:61388971
UT WOS	000517851700010
EID SCOPUS	85078993869
DOI	10.1016/j.biomaterials.2019.119728
Annotation	Design, controlled synthesis, physico-chemical and biological characteristics of novel well-defined biodegradable star-shaped copolymers intended for advanced drug delivery is described. These new biocompatible star copolymers were synthesised by grafting monodispersed semitelechelic linear (sL) N-(2-hydroxypropyl)methacrylamide copolymers onto a 2,2-bis(hydroxymethyl)propionic acid (bisMPA)-based polyester dendritic core of various structures. The hydrodynamic diameter of the star copolymer biomaterials can be tuned from 13 to 31 nm and could be adjusted to a given purpose by proper selection of the bisMPA dendritic core type and generation and by considering the sL copolymer molecular weight and polymer-to-core molar ratio. The hydrolytic degradation was proved for both the star copolymers containing either dendron or dendrimer core, showing the spontaneous hydrolysis in duration of few weeks. Finally, it was shown that the therapy with the biodegradable star conjugate with attached doxorubicin strongly suppresses the tumour growth in mice and is fully curative in most of the treated animals at dose corresponding approximately to one fourth of maximum tolerated dose (MTD) value. Both new biodegradable systems show superior efficacy and tumour accumulation over the first generation of star copolymers containing non-degradable PAMAM core.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2021
Electronic address	https://www.sciencedirect.com/science/article/pii/S0142961219308464?via%3Dihub

Number of the records: 1