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The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy
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SYSNO ASEP 0521636 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy Author(s) Plzák, J. (CZ)
Bouček, J. (CZ)
Bandurova, V. (CZ)
Kolář, Michal (UMG-J) RID, ORCID
Hradilová, Miluše (UMG-J)
Szabo, P. (CZ)
Lacina, L. (CZ)
Chovanec, M. (CZ)
Smetana, K. (CZ)Number of authors 9 Article number 440 Source Title Cancers (Basel). - : MDPI
Roč. 11, č. 4 (2019)Number of pages 19 s. Publication form Online - E Language eng - English Country CH - Switzerland Keywords cancer ; cancer microenvironment ; cancer ecosystem ; cancer-associated fibroblast ; extracellular matrix ; cytokine ; il-6 ; tumour-associated macrophages ; cancer therapy Subject RIV EB - Genetics ; Molecular Biology OECD category Biochemistry and molecular biology R&D Projects LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UMG-J - RVO:68378050 UT WOS 000467773400008 DOI 10.3390/cancers11040440 Annotation Similarly to other types of malignant tumours, the incidence of head and neck cancer is increasing globally. It is frequently associated with smoking and alcohol abuse, and in a broader sense also with prolonged exposure to these factors during ageing. A higher incidence of tumours observed in younger populations without a history of alcohol and tobacco abuse may be due to HPV infection. Malignant tumours form an intricate ecosystem of cancer cells, fibroblasts, blood/lymphatic capillaries and infiltrating immune cells. This dynamic system, the tumour microenvironment, has a significant impact on the biological properties of cancer cells. The microenvironment participates in the control of local aggressiveness of cancer cells, their growth, and their consequent migration to lymph nodes and distant organs during metastatic spread. In cancers originating from squamous epithelium, a similarity was demonstrated between the cancer microenvironment and healing wounds. In this review, we focus on the specificity of the microenvironment of head and neck cancer with emphasis on the mechanism of intercellular crosstalk manipulation for potential therapeutic application. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2020 Electronic address https://www.mdpi.com/2072-6694/11/4/440
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