Remote actuation of apoptosis in liver cancer cells via magneto-mechanical modulation of iron oxide nanoparticles

Lunov, Oleg; Uzhytchak, Mariia; Smolková, Barbora; Lunova, Mariia; Jirsa, M.; Dempsey, N.M.; Dias, A.L.; Bonfim, M.; Hof, Martin; Jurkiewicz, Piotr; Petrenko, Y.; Kubinová, Šárka; Dejneka, Alexandr

doi:https://dx.doi.org/10.3390/cancers11121873

Number of the records: 1

Remote actuation of apoptosis in liver cancer cells via magneto-mechanical modulation of iron oxide nanoparticles

1.

SYSNO ASEP	0521399
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Remote actuation of apoptosis in liver cancer cells via magneto-mechanical modulation of iron oxide nanoparticles
Author(s)	Lunov, Oleg (FZU-D)_ORCID Uzhytchak, Mariia (FZU-D)_ORCID Smolková, Barbora (FZU-D)_ORCID Lunova, Mariia (FZU-D)_ORCID Jirsa, M. (CZ) Dempsey, N.M. (FR) Dias, A.L. (FR) Bonfim, M. (BR) Hof, Martin (UFCH-W)_{RID, ORCID} Jurkiewicz, Piotr (UFCH-W)_{RID, ORCID} Petrenko, Y. (UA) Kubinová, Šárka (FZU-D)_{RID, ORCID} Dejneka, Alexandr (FZU-D)_{RID, ORCID}
Number of authors	13
Article number	1873
Source Title	Cancers (Basel). - : MDPI Roč. 11, č. 12 (2019), s. 1-21
Number of pages	21 s.
Language	eng - English
Country	CH - Switzerland
Keywords	pulsed magnetic field ; lysosomal membrane permeabilization ; magnetic nanoparticles ; lysosomal death pathways ; apoptosis
Subject RIV	BO - Biophysics
OECD category	Biophysics
Subject RIV - cooperation	J. Heyrovsky Institute of Physical Chemistry - Physical ; Theoretical Chemistry
R&D Projects	EF16_019/0000760 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Open access
Institutional support	FZU-D - RVO:68378271 ; UFCH-W - RVO:61388955
UT WOS	000507382100052
EID SCOPUS	85075713911
DOI	10.3390/cancers11121873
Annotation	Lysosome-activated apoptosis represents an alternative method of overcoming tumor resistance compared to traditional forms of treatment. Pulsed magnetic fields open a new avenue for controlled and targeted initiation of lysosomal permeabilization in cancer cells via mechanical actuation of magnetic nanomaterials. In this study we used a noninvasive tool, namely, a benchtop pulsed magnetic system, which enabled remote activation of apoptosis in liver cancer cells. The magnetic system we designed represents a platform that can be used in a wide range of biomedical applications. Overall, our results show that PMF treatment of SPION-loaded lysosomes can be utilized as a noninvasive tool to remotely induce apoptosis.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2020
Electronic address	http://hdl.handle.net/11104/0306030

Number of the records: 1