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Nitrogen enriched C:H:N:O thin films for improved antibiotics doping
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SYSNO ASEP 0519779 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nitrogen enriched C:H:N:O thin films for improved antibiotics doping Author(s) Kratochvíl, J. (CZ)
Kahoun, D. (CZ)
Kylián, O. (CZ)
Štěrba, Ján (BC-A) RID, ORCID
Kretková, T. (CZ)
Kousal, J. (CZ)
Hanuš, J. (CZ)
Vaclova, J. (CZ)
Prysiazhnyi, V. (CZ)
Sezemský, P. (CZ)
Fojtíková, P. (CZ)
Lieskovská, Jaroslava (BC-A) RID
Langhansová, H. (CZ)
Krakovský, I. (CZ)
Straňák, V. (CZ)Number of authors 15 Source Title Applied Surface Science. - : Elsevier - ISSN 0169-4332
Roč. 494, NOV 15 2019 (2019), s. 301-308Number of pages 8 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords antibacterial surfaces ; controlled-release ; solute release ; coatings ; ciprofloxacin ; prevention ; deposition ; implants ; titanium ; Antibiotics ; Impregnation ; Drug delivery ; Plasma polymer ; Magnetron sputtering ; Thin films Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology Method of publishing Limited access Institutional support BC-A - RVO:60077344 UT WOS 000487838900036 EID SCOPUS 85069718946 DOI 10.1016/j.apsusc.2019.07.135 Annotation In this study we investigate the ability of RF magnetron sputtered nylon 6,6 films (C:H:N:O) to store and release two model antibiotics, ampicillin and ciprofloxacin, that differ significantly in their chemical structure. We demonstrate that the addition of nitrogen to the deposition process leads to a substantial enhancement in the abundance of nitrogen-containing functional groups in the resulting coatings as well as to the significant changes in their swelling and dissolution. These variations were found to result in different impregnation and release capabilities of the produced coatings:an almost 5 times higher amount of released antibiotics was observed for the samples prepared in nitrogen-rich atmosphere when compared to films deposited in pure argon. It was also found that the amount of released antibiotics strongly depends on the natural character of the antibiotics used. However, it is demonstrated that minimum inhibitory concentrations against S. epidermidis and E. coli can be exceeded for both antibiotics. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2020 Electronic address https://www.sciencedirect.com/science/article/pii/S0169433219321713
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