Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?

Procházková, Eliška; Hřebabecký, Hubert; Dejmek, Milan; Šála, Michal; Šmídková, Markéta; Tloušťová, Eva; Zborníková, Eva; Eyer, Luděk; Růžek, Daniel; Nencka, Radim

doi:https://dx.doi.org/10.1016/j.bmcl.2019.126897

Number of the records: 1

Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?

1.

SYSNO ASEP	0519335
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Could 5′-N and S ProTide analogues work as prodrugs of antiviral agents?
Author(s)	Procházková, Eliška (UOCHB-X)_{RID, ORCID} Hřebabecký, Hubert (UOCHB-X)_{RID, ORCID} Dejmek, Milan (UOCHB-X)_{RID, ORCID} Šála, Michal (UOCHB-X)_{RID, ORCID} Šmídková, Markéta (UOCHB-X)_{RID, ORCID} Tloušťová, Eva (UOCHB-X)_{RID, ORCID} Zborníková, Eva (UOCHB-X)_{RID, ORCID} Eyer, Luděk (BC-A)_{RID, ORCID} Růžek, Daniel (BC-A)_{RID, ORCID} Nencka, Radim (UOCHB-X)_{RID, ORCID}
Article number	126897
Source Title	Bioorganic and Medicinal Chemistry Letters. - : Elsevier - ISSN 0960-894X Roč. 30, č. 4 (2020)
Number of pages	4 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	antiviral ; nucleotide ; prodrug ; ProTide ; HCV ; 31P NMR spectroscopy
Subject RIV	CC - Organic Chemistry
OECD category	Organic chemistry
Subject RIV - cooperation	Biology Centre (since 2006) - Microbiology, Virology
R&D Projects	NV16-34238A GA MZd - Ministry of Health (MZ)
	EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LO1302 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Method of publishing	Limited access
Institutional support	UOCHB-X - RVO:61388963 ; BC-A - RVO:60077344
UT WOS	000507987200013
EID SCOPUS	85077142100
DOI	10.1016/j.bmcl.2019.126897
Annotation	The nucleoside/nucleotide derived antiviral agents have been the most important components of antiviral therapy used in clinics. Recently, the focus of the medicinal chemists within this exciting research field has been affected mainly by the lack of effective therapies for the Hepatitis C virus (HCV) infection and several other “neglected” diseases caused by viruses such as Zika or Dengue. 2′-Methyl modified nucleosides and their monophosphate prodrugs (ProTides) have revolutionized the therapies for HCV in the last few years and, according to the latest research efforts, have also brought a promise for treatment of diseases caused by other members of Flaviviridae family. Here, we report on the design and synthesis of 5’-N and S modified ProTides derived from 2′-methyladenosine. We studied potential applicability of these derivatives as prodrugs of this archetypal antiviral compound.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2021
Electronic address	https://www.sciencedirect.com/science/article/pii/S0960894X19308753?via%3Dihub

Number of the records: 1