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Message in a vesicle trans-kingdom intercommunication at the vector-host interface
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SYSNO ASEP 0518848 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Message in a vesicle trans-kingdom intercommunication at the vector-host interface Author(s) Chávez, A.S.O. (US)
O'Neal, A.J. (US)
Santambrogio, L. (US)
Kotsyfakis, Michalis (BC-A) RID, ORCID
Pedra, J. H. F. (US)Number of authors 5 Article number jcs224212 Source Title Journal of Cell Science. - : Company of Biologists - ISSN 0021-9533
Roč. 132, č. 6 (2019)Number of pages 11 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords extracellular vesicles ; trypanosoma-cruzi ; proteomic analysis ; protein ; exosomes ; parasite ; tick ; leishmania ; secretion ; membrane ; Extracellular vesicle ; Arthropod-borne disease ; Cell communication ; Immunomodulation ; Microbial transmission Subject RIV EA - Cell Biology OECD category Cell biology Method of publishing Open access Institutional support BC-A - RVO:60077344 UT WOS 000462864300011 EID SCOPUS 85063290362 DOI 10.1242/jcs.224212 Annotation Vector-borne diseases cause over 700,000 deaths annually and represent 17% of all infectious illnesses worldwide. This public health menace highlights the importance of understanding how arthropod vectors, microbes and their mammalian hosts interact. Currently, an emphasis of the scientific enterprise is at the vector-host interface where human pathogens are acquired and transmitted. At this spatial junction, arthropod effector molecules are secreted, enabling microbial pathogenesis and disease. Extracellular vesicles manipulate signaling networks by carrying proteins, lipids, carbohydrates and regulatory nucleic acids. Therefore, they are well positioned to aid in cell-to-cell communication and mediate molecular interactions. This Review briefly discusses exosome and microvesicle biogenesis, their cargo, and the role that nanovesicles play during pathogen spread, host colonization and disease pathogenesis. We then focus on the role of extracellular vesicles in dictating microbial pathogenesis and host immunity during transmission of vector-borne pathogens. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2020 Electronic address https://jcs.biologists.org/content/joces/132/6/jcs224212.full.pdf
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