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Design of the reversible biphasic arrangement in the microfluidic chip reactor for asymmetric hydrogenation reactions.
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SYSNO ASEP 0518838 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Design of the reversible biphasic arrangement in the microfluidic chip reactor for asymmetric hydrogenation reactions. Author(s) Klusoň, Petr (UCHP-M) RID, ORCID, SAI
Stavárek, Petr (UCHP-M) RID, ORCID, SAI
Pěnkavová, Věra (UCHP-M) RID, ORCID, SAI
Vychodilová, Hana (UCHP-M) RID, SAI
Hejda, Stanislav (UCHP-M) RID, ORCID, SAI
Bendová, Magdalena (UCHP-M) RID, ORCID, SAI
Došek, M. (CZ)Source Title Chemical Engineering Research and Design. - : Elsevier - ISSN 0263-8762
Roč. 153, January (2020), s. 537-546Number of pages 10 s. Language eng - English Country NL - Netherlands Keywords reversible biphasic system ; microfluidic chip reactor ; catalyst recovery Subject RIV CI - Industrial Chemistry, Chemical Engineering OECD category Chemical process engineering R&D Projects GA15-04790S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UCHP-M - RVO:67985858 UT WOS 000510526400045 EID SCOPUS 85075591042 DOI 10.1016/j.cherd.2019.11.023 Annotation Design of the reversible biphasic system for a practical use in asymmetric hydrogenation performed in a microfluidic chip reactor is reported. Methylacetoacetate (MAA) was transformed to (R)-methylhydroxybutyrate over optically pure (R)-Ru-BINAP as a model reaction. The study was an iteration towards the design, description and optimization of the temperature driven reversible biphasic system in the mixed [NR,222][Tf2N]/methanol/water phase by varying the parameter of the structure of the ionic molecule, starting from [NH4][Tf2N] up to [N14,222][Tf2N]. At temperatures, and other conditions providing high conversions and optical yields, the reaction mixture was monophasic. At lower temperatures, the mixture became biphasic for ionic liquids with long alkyl chains (namely [N14,222][Tf2N]) due to their strong non-polar character. The formed ionic liquid phase accommodated the chiral Ru complex, the water/methanol phase the reaction products. After the reaction, when the mixture was cooled, over 90% of the catalytic complex was kept in the ionic liquid phase. Viscosity and density data were also discussed. It seems the reversible biphasic system offers a way to facilitate the separation of the chiral Ru-complex from the reaction mixture. Due to high sensitivity of the complex to handling conditions, its reuse still requires further optimization. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S0263876219305490?via%3Dihub
Number of the records: 1