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Analytical approaches for characterizing and quantifying engineered nanoparticles in biological matrices from an (eco)toxicological perspective: old challenges, new methods and techniques
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SYSNO ASEP 0518608 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Analytical approaches for characterizing and quantifying engineered nanoparticles in biological matrices from an (eco)toxicological perspective: old challenges, new methods and techniques Author(s) Monikh, F. A. (NL)
Chupani, L. (CZ)
Vijver, M. G. (NL)
Vancová, Marie (BC-A) RID, ORCID
Peijnenburg, W. J. G. M. (NL)Number of authors 5 Source Title Science of the Total Environment. - : Elsevier - ISSN 0048-9697
Roč. 660, APR 10 2019 (2019), s. 1283-1293Number of pages 11 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords particle icp-ms ; plasma-mass spectrometry ; field-flow fractionation ; walled carbon nanotubes ; titanium-dioxide nanoparticles ; zinc-oxide nanoparticles ; silver nanoparticles ; gold nanoparticles ; environmental-samples ; quantitative-analysis ; Nanoparticles ; Complex matrices ; Ecotoxicology ; Analytical techniques ; Sample preparation Subject RIV EB - Genetics ; Molecular Biology OECD category Genetics and heredity (medical genetics to be 3) R&D Projects LM2015062 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support BC-A - RVO:60077344 UT WOS 000457725700125 EID SCOPUS 85059962554 DOI 10.1016/j.scitotenv.2019.01.105 Annotation To promote the safer by design strategy and assess environmental risks of engineered nanoparticles (ENPs), it is essential to understand the fate of ENPs within organisms. This understanding in living organisms is limited by challenges in characterizing and quantifying ENPs in biological media. Relevant literature in this area is scattered across research from the past decade or so, and it consists mostly of medically oriented studies. This review first introduces those modern techniques and methods that can be used to extract, characterize, and quantify ENPs in biological matrices for (eco)toxicological purposes. It then summarizes recent research developments within those areas most relevant to the context and field that are the subject of this review paper. These comprise numerous in-situ techniques and some ex-situ techniques. The former group includes techniques allowing to observe specimens in their natural hydrated state (e.g., scanning electron microscopy working in cryo mode and high-pressure freezing) and microscopy equipped with elemental microanalysis (e.g., energy-dispersive X-ray spectroscopy), two-photon laser and coherent anti-Stokes Raman scattering microscopy, absorption-edge synchrotron X-ray computed microtomography, and laser ablation-inductively coupled plasma mass spectrometry (LA-ICP-MS). The latter group includes asymmetric flow field flow fractionation coupled with ICP-MS and single particle-ICP-MS. Our review found that most of the evidence gathered for ENPs actually focused on a few metal-based ENPs and carbon nanotube and points to total mass concentration but no other particles properties, such as size and number. Based on the obtained knowledge, we developed and presented a decision scheme and analytical toolbox to help orient scientists toward selecting appropriate ways for investigating the (eco)toxicity of ENPs that are consistent with their properties. (c) 2019 Elsevier B.V. All rights reserved. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2020 Electronic address https://www.sciencedirect.com/science/article/pii/S0048969719301226
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