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Preparation of PSEBS membranes bearing (S)-(−)-methylbenzylamine as chiral selector
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SYSNO ASEP 0518380 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Preparation of PSEBS membranes bearing (S)-(−)-methylbenzylamine as chiral selector Author(s) Otmar, Miroslav (UMCH-V) RID, ORCID
Gaálová, Jana (UCHP-M) RID, SAI, ORCID
Žitka, Jan (UMCH-V) RID
Brožová, Libuše (UMCH-V) RID, ORCID
Cuřínová, Petra (UCHP-M) RID, SAI, ORCID
Kohout, M. (CZ)
Hovorka, Š. (CZ)
Bara, J. E. (US)
Van der Bruggen, B. (BE)
Jirsák, J. (CZ)
Izák, Pavel (UCHP-M) RID, ORCID, SAIArticle number 109381 Source Title European Polymer Journal. - : Elsevier - ISSN 0014-3057
Roč. 122, 5 January (2020), s. 1-6Number of pages 6 s. Language eng - English Country GB - United Kingdom Keywords optical resolution ; racemic mixture ; membrane technology Subject RIV CI - Industrial Chemistry, Chemical Engineering OECD category Chemical process engineering Subject RIV - cooperation Institute of Chemical Process Fundamentals - Industrial Chemistry, Chemical Engineering R&D Projects GA17-00089S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 ; UCHP-M - RVO:67985858 UT WOS 000509784900049 EID SCOPUS 85076056630 DOI 10.1016/j.eurpolymj.2019.109381 Annotation Nowadays, there is a strong need for replacement of racemates by enantiomerically pure drugs. Enantioseparation on polymer membranes seems to be one of the promising and economically feasible technologies for this purpose. As a material for membrane construction, linear polymer molecules bearing covalently bonded chiral selectors are very promising according to recent reports. A membrane formed from chloromethylated polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene (PSEBS) was cast and subsequently functionalized with a chiral selector (S)-(−)-α-methylbenzylamine. In preferential sorption experiments with racemic tryptophan and ibuprofen, the prepared membrane exhibited a higher affinity to l-tryptophan and (R)-(−)-ibuprofen than to corresponding enantiomers. The significant change in peak ratio from 48:52 to 60:40 (d-tryptophan:l-tryptophan) was observed. This indicates the high potential of the covalently bonded (S)-(−)-α-methylbenzylamine selector for the fabrication of membranes selective towards chiral acids and ampholytes. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S0014305719311930?via%3Dihub
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