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pH-responsive and antibacterial properties of self-assembled multilayer films based on chitosan and tannic acid
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SYSNO ASEP 0518031 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title pH-responsive and antibacterial properties of self-assembled multilayer films based on chitosan and tannic acid Author(s) Kumorek, Marta M. (UMCH-V) RID
Minisy, Islam M. (UMCH-V) RID, ORCID
Krunclová, Tereza (UMCH-V) ORCID
Voršiláková, Marta (UMCH-V)
Venclíková, Kristýna (UMCH-V) RID
Mázl Chánová, Eliška (UMCH-V) RID
Janoušková, Olga (UMCH-V) RID, SAI, ORCID
Kubies, Dana (UMCH-V) RID, ORCIDArticle number 110493 Source Title Materials Science & Engineering C-Materials for Biological Applications. - : Elsevier - ISSN 0928-4931
Roč. 109, April (2020), s. 1-13Number of pages 13 s. Language eng - English Country NL - Netherlands Keywords tannic acid ; chitosan ; layer-by-layer Subject RIV CD - Macromolecular Chemistry OECD category Polymer science R&D Projects ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LQ1604 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) NV16-28254A GA MZd - Ministry of Health (MZ) Method of publishing Limited access Institutional support UMCH-V - RVO:61389013 UT WOS 000527394600015 EID SCOPUS 85076174234 DOI 10.1016/j.msec.2019.110493 Annotation Polyelectrolyte layer-by-layer (LbL) films that disintegrate under physiological conditions are intensively studied as coatings to enable the release of bioactive components. Herein, we report on the interactions and pH-stability of LbL films composed of chitosan (CH) or N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (CMCH) and tannic acid (TA), employed to guarantee the film disintegration. The self-assembly of TA with CH and CMCH at pH 5 and with CMCH at pH 7.4 were proven by turbidimetric, surface plasmon resonance and UV–Vis analyses. The LbL films exhibited pH-dependent properties. CMCH/TA films prepared at pH 7.4 showed exponential growth as well as a higher layer thickness and surface roughness, whereas films prepared at pH 5 grew linearly and were smoother. The film stability varied with the pH used for film assembly. CH/TA films assembled at pH 5 were unstable at pH 8.5, whereas CMCH/TA films assembled at pH 7.4 disintegrated at pH 4. All films exhibited a similar disassembly at pH 7.4. The coatings reduced the adhesion of E. coli and S. aureus by approximately 80%. CMCH-terminated CMCH/TA films were more resistant to bacterial adhesion, whereas CH-terminated CH/TA films demonstrated stronger killing activity. The prepared pH-triggered decomposable LbL films could be used as degradable coatings that allow the release of therapeutics for biomedical applications and also prevent bacterial adhesion. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2021 Electronic address https://www.sciencedirect.com/science/article/pii/S0928493119303339?via%3Dihub
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