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Macromolecular conjugates for visualization and separation of proteins and cells
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SYSNO ASEP 0518013 Document Type P - Patent R&D Document Type Patent or other outcome protected by special legislation Title Macromolecular conjugates for visualization and separation of proteins and cells Author(s) Šácha, Pavel (UOCHB-X) RID, ORCID
Konvalinka, Jan (UOCHB-X) RID, ORCID
Schimer, Jiří (UOCHB-X) RID, ORCID
Knedlík, Tomáš (UOCHB-X) RID, ORCID
Navrátil, Václav (UOCHB-X) RID, ORCID
Tykvart, Jan (UOCHB-X) RID, ORCID
Sedlák, František (UOCHB-X) RID, ORCID
Majer, Pavel (UOCHB-X)
Cígler, Petr (UOCHB-X) RID, ORCID
Šubr, Vladimír (UMCH-V) RID, ORCID
Ulbrich, Karel (UMCH-V) RID
Strohalm, Jiří (UMCH-V)Year of issue 2018 Possible third party use of the result A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence Royalty requested A - Poskytovatel licence požaduje licenční poplatek Patent no. or utility model no. or industrial design no. AU2016207126 Date of the patent acceptance 29.11.2018 Name of the patent owner Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav makromolekulární chemie AV ČR, v. v. i. - Univerzita Karlova v Praze Code of the issuer name AU001 - IP Australia Phillip ACT Current use B - Patent je využíván na základě uzavřené licenční smlouvy mezi vlastníkem a uživatelem Language eng - English Keywords antibody mimetics ; flow cytometry ; ELISA ; protein targeting ; polymer conjugates ; molecular recognition ; HPMA Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology Subject RIV - cooperation Institute of Macromolecular Chemistry - Macromolecular Chemistry R&D Projects GA16-02938S GA ČR - Czech Science Foundation (CSF) LO1302 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UOCHB-X - RVO:61388963 ; UMCH-V - RVO:61389013 Annotation Macromolecular conjugates for visualization and separation of proteins and cells The present invention descripbes macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells both in vitro and in vivo. HPMA copolymer, i.e.poly(HPMA-co-Ma-β-Ala-TT), copolymer prepared by conventional solution radical polymerization or controlled radical copolymerization (e.g. RAFT copolymerization, reversible addition-fragmentation chain-transfer) of N-(2- hydroxypropyl)methacrylamide (HPMA) and 3-(3-methakrylamidopropanoyl)thiazolidine-2-thione (Ma-P-Ala-TT) can be preferably used as the basic copolymer. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2020 Electronic address https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20181129&DB=&locale=en_EP&CC=AU&NR=2016207126B2&KC=B2&ND=5#
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