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Extracellular polysaccharide produced by Chlorella vulgaris - Chemical characterization and anti-asthmatic profile
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SYSNO ASEP 0517850 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Extracellular polysaccharide produced by Chlorella vulgaris - Chemical characterization and anti-asthmatic profile Author(s) Barboríková, J. (SK)
Šutovská, M. (SK)
Kazimierová, I. (SK)
Jošková, M. (SK)
Frantová, S. (SK)
Kopecký, Jiří (MBU-M) ORCID
Čapek, P. (SK)Source Title International Journal of Biological Macromolecules. - : Elsevier - ISSN 0141-8130
Roč. 135, AUG 15 2019 (2019), s. 1-11Number of pages 11 s. Language eng - English Country NL - Netherlands Keywords Green microalgae ; Extracellular polysaccharide ; Anti-asthmatic effect Subject RIV CE - Biochemistry OECD category Biochemistry and molecular biology Method of publishing Limited access Institutional support MBU-M - RVO:61388971 UT WOS 000477691600001 EID SCOPUS 85066030442 DOI 10.1016/j.ijbiomac.2019.05.104 Annotation Microalgae are the lowest plant organisms producing a wide range of metabolites that make them interesting organisms for industrial applications. Cultivation of green microalgal species Chlorella vulgaris resulted a significant production of extracellular polysaccharide (EPS). Preliminary chemico-spectroscopic studies on EPS revealed its molecular profile, a complex primary structure consisting of six monosaccharide units occurring in both furano and pyrano forms, a high sugar binding variability and the presence of partially methylated derivatives of some sugar constituents. Biological activity tests showed that EPS caused significant bronchodilatory, anti-inflammatory and antitussive effects in test animals. Chlorella EPS appears to be a promising agent for the prevention of chronic airway inflammation, which is the basic pathogenic mechanism of many respiratory diseases, including bronchial asthma. Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2020 Electronic address https://www.jbc.org/content/294/29/11131
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