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Interaction pathways and structure-chemical transformations of alginate gels in physiological environments

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    SYSNO ASEP0510805
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleInteraction pathways and structure-chemical transformations of alginate gels in physiological environments
    Author(s) Urbanová, Martina (UMCH-V) RID, ORCID
    Pavelková, M. (CZ)
    Czernek, Jiří (UMCH-V) RID
    Kubová, K. (CZ)
    Vysloužil, J. (CZ)
    Pechová, A. (CZ)
    Molinková, D. (CZ)
    Vysloužil, J. (CZ)
    Vetchý, D. (CZ)
    Brus, Jiří (UMCH-V) RID, ORCID
    Source TitleBiomacromolecules. - : AMER CHEMICAL SOC - ISSN 1525-7797
    Roč. 20, č. 11 (2019), s. 4158-4170
    Number of pages13 s.
    Languageeng - English
    CountryUS - United States
    Keywordsalginate gels ; molecular-level interactions ; physiological conditions
    Subject RIVCD - Macromolecular Chemistry
    OBOR OECDPolymer science
    R&D ProjectsLO1507 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    LTAUSA18011 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    Způsob publikováníOmezený přístup
    Institutional supportUMCH-V - RVO:61389013
    UT WOS000496343800012
    EID SCOPUS85074441891
    AnnotationThe remarkably diverse affinity of alginate (ALG) macromolecules for polyvalent metal ions makes cross-linked alginate gels an outstanding biomaterial. Surprisingly, however, very little is known about their interactions and structural transformations in physiological environments. To bridge this gap, we prepared a set of ALG gels cross-linked by various ions and monitored their structural changes at different media simulating gastric and intestinal fluids and cellular environments. For these studies, we used multinuclear solid-state NMR (ss-NMR) spectroscopy, which revealed a range of competitive ion-exchange and interconversion reactions, the rate of which strongly depended on the nature of the cross-linking metal ions. Depending on the environment, ALG chains adopted different forms, such as acidic (hydro)gels stabilized by strong hydrogen bonds, and/or weakly cross-linked Na/H-gels. Simultaneously, the exchanged polyvalent ions extensively interacted with the environment even forming in some cases insoluble phosphate microdomains directly deposited in the ALG bead matrix. The extent of the transformations and incorporation of secondary phases into the alginate beads followed the size and electronegativity of the cross-linking ions. Overall, the applied combination of various macroscopic and biological tests with multinuclear ss-NMR revealed a complex pathway of alginate beads transformations in physiological environments.
    WorkplaceInstitute of Macromolecular Chemistry
    ContactEva Čechová, ; Tel.: 296 809 358
    Year of Publishing2020
    Electronic address
Number of the records: 1