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Recent achievements in medicinal and supramolecular chemistry of betulinic acid and its derivatives
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SYSNO ASEP 0509279 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Recent achievements in medicinal and supramolecular chemistry of betulinic acid and its derivatives Author(s) Bildziukevich, Uladzimir (UEB-Q) RID, ORCID
Özdemir, Zülal (UEB-Q) ORCID
Wimmer, Zdeněk (UEB-Q) RID, ORCIDNumber of authors 3 Article number 3546 Source Title Molecules. - : MDPI
Roč. 24, č. 19 (2019)Number of pages 20 s. Language eng - English Country CH - Switzerland Keywords ADME parameters ; Antitumor activity ; Antiviral activity ; Betulinic acid ; Cytotoxicity ; Physicochemical parameters ; Structural modification ; Supramolecular self-assembly Subject RIV CC - Organic Chemistry OECD category Chemical engineering (plants, products) R&D Projects FV10599 GA MPO - Ministry of Industry and Trade (MPO) FV30300 GA MPO - Ministry of Industry and Trade (MPO) Method of publishing Open access Institutional support UEB-Q - RVO:61389030 UT WOS 000496242300131 EID SCOPUS 85072762176 DOI 10.3390/molecules24193546 Annotation The subject of this review article refers to the recent achievements in the investigation of pharmacological activity and supramolecular characteristics of betulinic acid and its diverse derivatives, with special focus on their cytotoxic effect, antitumor activity, and antiviral effect, and mostly covers a period 2015–2018. Literature sources published earlier are referred to in required coherences or from historical points of view. Relationships between pharmacological activity and supramolecular characteristics are included if such investigation has been done in the original literature sources. A wide practical applicability of betulinic acid and its derivatives demonstrated in the literature sources is also included in this review article. Several literature sources also focused on in silico calculation of physicochemical and ADME parameters of the developed compounds, and on a comparison between the experimental and calculated data. Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2020 Electronic address http://dx.doi.org/10.3390/molecules24193546
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