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In Silico Study of the Effect of Humid air on Inhaled Aerosols in the Conducting Airways.
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SYSNO ASEP 0507975 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title In Silico Study of the Effect of Humid air on Inhaled Aerosols in the Conducting Airways. Author(s) Stylianou, F. (CY)
Koullapis, P. (CY)
Velaga, S. (SE)
Ždímal, Vladimír (UCHP-M) RID, ORCID, SAI
Kassinos, S. (CY)Article number O1_A7_S02 Source Title EAC -Online program. - - : Nordic Society for Aerosol Research, 2019 - ISBN N Number of pages 1 s. Publication form Online - E Action European Aerosol Conference EAC 2019 Event date 25.08.2019 - 30.08.2019 VEvent location Gothenburg Country SE - Sweden Event type EUR Language eng - English Country SE - Sweden Keywords in silico study ; hygroscopic growth effects ; inhaled aerosol deposition Subject RIV DN - Health Impact of the Environment Quality OECD category Public and environmental health Institutional support UCHP-M - RVO:67985858 Annotation Improving delivery efficiency of inhaled medications is of utmost importance, as it will lead to reduction of side effects associated with unwanted mouth-throat deposition, and reduction of treatment costs associated with decreased drug dosage. In addition, many next generation inhaled medications require precise targeting and dosing within the airways to be clinically acceptable, effective, and safe. In this direction, Longest et al. (2012) proposed the enhancement of drug particles with hygroscopic excipients. With appropriate selection of the initial size of the particles and the drug-excipient ratio, it is possible to achieve optimum drug delivery at targeted areas of the airways, by harnessing the natural high humidity environment of the airways. In this study, we evaluate the delivery efficiency of drug-excipient composites using high-fidelity numerical simulations. Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2020
Number of the records: 1