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Lenalidomide treatment in lower risk myelodysplastic syndromes-The experience of a Czech hematology center. (Positive effect of erythropoietin +/- prednisone addition to lenalidomide in refractory or relapsed patients)
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SYSNO ASEP 0506807 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lenalidomide treatment in lower risk myelodysplastic syndromes-The experience of a Czech hematology center. (Positive effect of erythropoietin +/- prednisone addition to lenalidomide in refractory or relapsed patients) Author(s) Jonasova, A. (CZ)
Neuwirtová, R. (CZ)
Polackova, H. (CZ)
Šišková, M. (CZ)
Stopka, T. (CZ)
Cmunt, E. (CZ)
Belickova, M. (CZ)
Moudrá, Alena (UMG-J)
Minařík, L. (CZ)
Fuchs, O. (CZ)
Michalová, K. (CZ)
Zemanová, Z. (CZ)Number of authors 12 Source Title Leukemia Research. - : Elsevier - ISSN 0145-2126
Roč. 69, June (2018), s. 12-17Number of pages 6 s. Publication form Online - E Language eng - English Country GB - United Kingdom Keywords Myelodysplastic syndromes ; Lenalidomide ; Del(5q) aberration ; Erythropoietin ; Prednisone Subject RIV EB - Genetics ; Molecular Biology OECD category Cell biology Method of publishing Limited access Institutional support UMG-J - RVO:68378050 UT WOS 000436483100003 DOI 10.1016/j.leukres.2018.03.015 Annotation Lenalidomide therapy represents meaningful progress in the treatment of anemic patients with myelodysplastic syndromes with del(5q). We present our initial lenalidomide experience and the positive effect of combining erythropoietin and steroids with lenalidomide in refractory and relapsed patients. We treated by lenalidomide 55 (42 female, 13 male, median age 69) chronically transfused lower risk MDS patients with del(5q) (45) and non-del( 5q) (10). Response, meaning transfusion independence (TI) lasting >= eight weeks, was achieved in 38 (90%) of analyzed patients with del(5q), of whom three achieved TI only by adding erythropoietin +/- prednisone. Another five patients responded well to this combination when their anemia relapsed later during the treatment. In the non-del(5q) group only one patient with RARS-T reached TI. Cytogenetic response was reached in 64% (32% complete, 32% partial response). The TP53 mutation was detected in 7 (18%) patients, four patients progressed to higher grade MDS or acute myeloid leukemia (AML). All seven RAEB-1 patients cleared bone marrow blasts during lenalidomide treatment and reached complete remission (CR), however, three later progressed to higher grade MDS or AML. Lenalidomide represents effective treatment for del(5q) group and combination with prednisone and erythropoietin may be used for non-responders or therapy failures. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2020 Electronic address https://www.sciencedirect.com/science/article/abs/pii/S0145212618300778?via%3Dihub
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