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The Role of Tyrosine Oxidation in Structures and Properties of Neurodegenerative Peptides and Proteins

SYSNO ASEP	0504590
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	Conference Paper
Title	The Role of Tyrosine Oxidation in Structures and Properties of Neurodegenerative Peptides and Proteins
Author(s)	Niederhafner, Petr (UOCHB-X)_ORCID Brichtová, Eva (UOCHB-X)_ORCID Šafařík, Martin (UOCHB-X)_ORCID Kiederling, T. A. (US) Šebestík, Jaroslav (UOCHB-X)_{RID, ORCID}
Source Title	Peptide Science 2018: Proceedings of the 10th International Peptide Symposium / the 55th Japanese Peptide Symposium. - Osaka : Japanese Peptide Society, 2019 ; Futaki S. ; Matsuzaki K. - ISSN 1344-7661 - ISBN 978-4-931541-191
Pages	s. 59-60
Number of pages	2 s.
Publication form	Print - P
Action	International Peptide Symposium /10./ and Japanese Peptide Symposium /55./
Event date	03.12.2018 - 07.12.2018
VEvent location	Kyoto
Country	JP - Japan
Event type	WRD
Language	eng - English
Country	JP - Japan
Keywords	chiroptical spectroscopies ; protein-protein interactions ; tyrosine oxidation
Subject RIV	BO - Biophysics
OECD category	Biophysics
R&D Projects	GA17-00121S GA ČR - Czech Science Foundation (CSF)
	EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UOCHB-X - RVO:61388963
Annotation	Neurodegenerative diseases are influenced by oxidative stress. We selectively synthesized oxidized peptides with 3-nitrotyrosine (Nit), and 3-chlorotyrosine (Cly). We have investigated the influence of these oxidized tyrosines on solubility, hydrophobicity, and structure of alpha-synuclein model peptides.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2020

Number of the records: 1