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Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP
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SYSNO ASEP 0503586 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP Author(s) Piggott, L. (GB)
Silva, A. (GB)
Robinson, T. (GB)
Santiago-Gomez, A. (GB)
Simoes, B. M. (GB)
Becker, M. (DE)
Fichtner, I. (DE)
Anděra, Ladislav (BTO-N)
Young, P. (GB)
Morris, Ch. (GB)
Barrett-Lee, P. (GB)
Alchami, F. (GB)
Piva, M. (ES)
Vivanco, M. D. (ES)
Clarke, R. B. (GB)
Gee, J. (GB)
Clarkson, R. (GB)Number of authors 17 Source Title Clinical Cancer Research. - : American Association for Cancer Research - ISSN 1078-0432
Roč. 24, č. 10 (2018), s. 2452-2463Number of pages 12 s. Language eng - English Country US - United States Keywords FLICE inhibitory protein recombinant tumor necrosis factor related apoptosis inducing ligand ; fulvestrant ; recombinant tumor necrosis factor related apoptosis inducing ligand Subject RIV FD - Oncology ; Hematology OECD category Oncology Institutional support BTO-N - RVO:86652036 UT WOS 000432329600024 EID SCOPUS 85046169877 DOI 10.1158/1078-0432.CCR-17-1381 Annotation Purpose: One third of ER-positive breast cancer patients who initially respond to endocrine therapy become resistant to treatment. Such treatment failure is associated with poor prognosis and remains an area of unmet clinical need. Here, we identify a specific posttranslational modification that occurs during endocrine resistance and which results in tumor susceptibility to the apoptosis-inducer TRAIL. This potentially offers a novel stratified approach to targeting endocrine-resistant breast cancer. Workplace Institute of Biotechnology Contact Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700 Year of Publishing 2019
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