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Monolithic intercalated PNIPAm/starch hydrogels with very fast and extensive one-way volume and swelling responses to temperature and pH: prospective actuators and drug release systems

SYSNO ASEP	0500392
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Monolithic intercalated PNIPAm/starch hydrogels with very fast and extensive one-way volume and swelling responses to temperature and pH: prospective actuators and drug release systems
Author(s)	Strachota, Beata (UMCH-V)_RID Strachota, Adam (UMCH-V)_{RID, ORCID} Šlouf, Miroslav (UMCH-V)_{RID, ORCID} Brus, Jiří (UMCH-V)_{RID, ORCID} Cimrová, Věra (UMCH-V)_{RID, ORCID}
Source Title	Soft Matter - ISSN 1744-683X Roč. 15, č. 4 (2019), s. 752-769
Number of pages	18 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	temperature-sensitive hydrogel ; pH-sensitive hydrogel ; drug release
Subject RIV	CD - Macromolecular Chemistry
OECD category	Polymer science
R&D Projects	TE01020118 GA TA ČR - Technology Agency of the Czech Republic (TA ČR)
	LO1507 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GC18-14683J GA ČR - Czech Science Foundation (CSF)
Method of publishing	Limited access
Institutional support	UMCH-V - RVO:61389013
UT WOS	000457329700016
EID SCOPUS	85060374952
DOI	10.1039/C8SM02153H
Annotation	Remarkable monolithic (non-porous) hydrogels based on poly(NIPAm-co-sodium methacrylate) intercalated by starch were prepared, and were found to display very fast and extensive one-way solvent (water) release, induced by both pH and temperature. With centimeter-sized 3D specimens, the achieved response times were as short as 4 min (for 70% water release), in combination with very large volume responses (shrinking ratios up to 15). The response time can be tuned from minutes, over tens of minutes, up to hours. The pH-induced deswelling is always slower than the temperature-induced one, but at the highest starch content, ca. 5.5 min are needed for 70% completion of the pH-triggered process. Simultaneous temperature- and pH-stimuli expectedly also lead to very fast water release. The unique intercalated structure and the temperature-dependent hydrogen bridging between the intercalated phases, as well as between these phases and water, were found to play the key role in the ability of the gels to rapidly release water and shrink, which was deeper elucidated in this work. The hydrogels are of interest as soft actuators, but also for chemical release systems or for drug release applications. The latter was successfully tested with theophylline as the drug.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2020
Electronic address	https://pubs.rsc.org/en/content/articlelanding/2019/SM/C8SM02153H#!divAbstract

Number of the records: 1