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Macromolecular conjugates for isolation, immobilization and visualization of proteins

SYSNO ASEP	0500200
Document Type	P - Patent
R&D Document Type	Patent or other outcome protected by special legislation
Title	Macromolecular conjugates for isolation, immobilization and visualization of proteins
Author(s)	Šácha, Pavel (UOCHB-X)_{RID, ORCID} Konvalinka, Jan (UOCHB-X)_{RID, ORCID} Schimer, Jiří (UOCHB-X)_{RID, ORCID} Knedlík, Tomáš (UOCHB-X)_{RID, ORCID} Šubr, Vladimír (UMCH-V)_{RID, ORCID} Ulbrich, Karel (UMCH-V)_RID Strohalm, Jiří (UMCH-V)
Year of issue	2018
Possible third party use of the result	A - Pro využití výsledku jiným subjektem je vždy nutné nabytí licence
Royalty requested	A - Poskytovatel licence požaduje licenční poplatek
Patent no. or utility model no. or industrial design no.	AU2016207125
Date of the patent acceptance	17.05.2018
Name of the patent owner	Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav makromolekulární chemie AV ČR, v. v. i. - Univerzita Karlova v Praze
Code of the issuer name	AU001 - IP Australia Phillip ACT
Current use	B - Patent je využíván na základě uzavřené licenční smlouvy mezi vlastníkem a uživatelem
Language	eng - English
Keywords	antibody mimetics ; polymer ; His tag
Subject RIV	CE - Biochemistry
OECD category	Biochemistry and molecular biology
Subject RIV - cooperation	Institute of Macromolecular Chemistry - Macromolecular Chemistry
R&D Projects	GA16-02938S GA ČR - Czech Science Foundation (CSF)
	LO1302 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	NV15-31379A GA MZd - Ministry of Health (MZ)
Institutional support	UOCHB-X - RVO:61388963 ; UMCH-V - RVO:61389013
Annotation	Macromolecular conjugates for isolation, immobilization and visualization of proteins The invention provides a synthetic macromolecular conjugate for selective interaction with proteins, comprising a synthetic copolymer, and at least one binding group and at least one further group selected from an affinity tag and an imaging probe, said at least one binding group and at least one further group being bound via covalent bond to said synthetic copolymer. The macromolecular conjugate is suitable in particular for identification, visualization, quantification or isolation of proteins and/ or cells. HPMA copolymer, i.e.poly(HPMA-co-Ma-β-Ala-TT), a copolymer prepared by conventional solution radical polymerization or controlled radical copolymerization (e.g. RAFT copolymerization, reversible addition-fragmentation chain-transfer) of N-(2- hydroxypropyl) methacrylamide (HPMA) and 3-(3-methacrylamidopropanoyl) thiazolidine-2-thione (Ma-P-Ala-TT) can be preferably used as the basic copolymer.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2019
Electronic address	https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20180517&DB=&locale=en_EP&CC=AU&NR=2016207125B2&KC=B2&ND=4#

Number of the records: 1