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Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

SYSNO ASEP	0498725
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
Author(s)	Chang, W.C. (GB) Kudláček, Jan (FGU-C)_ORCID Hlinka, Jaroslav (UIVT-O)_{RID, SAI, ORCID} Chvojka, Jan (FGU-C)_ORCID Hadrava, Michal (UIVT-O)_{RID, ORCID, SAI} Kumpošt, Vojtěch (FGU-C)_ORCID Powell, A. D. (GB) Janča, R. (CZ) Maturana, M. I. (AU) Karoly, P. J. (AU) Freestone, D. R. (AU) Cook, M. J. (AU) Paluš, Milan (UIVT-O)_{RID, SAI, ORCID} Otáhal, Jakub (FGU-C)_{RID, ORCID, SAI} Jefferys, J. G. R. (GB) Jiruška, Přemysl (FGU-C)_{RID, ORCID, SAI}
Source Title	Nature Neuroscience. - : Nature Publishing Group - ISSN 1097-6256 Roč. 21, č. 12 (2018), s. 1742-1752
Number of pages	11 s.
Language	eng - English
Country	US - United States
Keywords	seizures ; dynamics ; perturbations ; transition to seizure ; critical slowing ; catastrophic shifts ; high-frequency activity ; interictal epileptiform discharges
Subject RIV	FH - Neurology
OECD category	Neurosciences (including psychophysiology
R&D Projects	GA14-02634S GA ČR - Czech Science Foundation (CSF)
	NV15-29835A GA MZd - Ministry of Health (MZ)
	NV17-28427A GA MZd - Ministry of Health (MZ)
Institutional support	FGU-C - RVO:67985823 ; UIVT-O - RVO:67985807
UT WOS	000451324700012
EID SCOPUS	85057290648
DOI	10.1038/s41593-018-0278-y
Annotation	The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2019

Number of the records: 1