Number of the records: 1

Targeting nanoparticles to modulate mTOR activity in cancer cells

SYSNO ASEP	0498007
Document Type	A - Abstract
R&D Document Type	The record was not marked in the RIV
R&D Document Type	Není vybrán druh dokumentu
Title	Targeting nanoparticles to modulate mTOR activity in cancer cells
Author(s)	Lunova, M. (CZ) Prokhorov, Andriy (FZU-D)_ORCID Jirsa, M. (CZ) Hof, Martin (UFCH-W)_{RID, ORCID} Olžyńska, Agnieszka (UFCH-W)_RID Jurkiewicz, Piotr (UFCH-W)_{RID, ORCID} Kubinová, Šárka (UEM-P)_{RID, ORCID} Lunov, Oleg (FZU-D)_ORCID Dejneka, Alexandr (FZU-D)_{RID, ORCID}
Number of authors	9
Source Title	FEBS Open Bio . - : Wiley - ISSN 2211-5463 Roč. 8, July (2018), s. 93-94
Number of pages	2 s.
Publication form	Online - E
Language	eng - English
Country	GB - United Kingdom
Keywords	mesoporous silica nanoparticles ; iron-oxide nanoparticles ; double-stranded-rna ; drug-delivery
Subject RIV	BM - Solid Matter Physics ; Magnetism
OECD category	Condensed matter physics (including formerly solid state physics, supercond.)
R&D Projects	LO1409 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LM2015088 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	FZU-D - RVO:68378271 ; UFCH-W - RVO:61388955 ; UEM-P - RVO:68378041
UT WOS	000437674101009
DOI	10.1002/2211-5463.12452
Annotation	Cancer is a major public health problem worldwide and is the second leading cause of death in the world. In recent years, there has been an unprecedented expansion in the field of nanomedicine with the development of new nanoparticles for the diagnosis and treatment of cancer. Yet, we still possess incomplete understanding of nano–bio interactions on ellular and molecular.levels. Such gap in the knowledge creates hurdles for clinical translation and commercialization of nanomedicines. Here we demonstrate that amino-functionalized polystyrene nanoparticles trigger cell death in hepatocellular carcinoma cells.
Workplace	Institute of Physics
Contact	Kristina Potocká, potocka@fzu.cz, Tel.: 220 318 579
Year of Publishing	2019

Number of the records: 1