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Determination of stability constants of antamanide complexes with sodium and potassium ions by affinity capillary electrophoresis

SYSNO ASEP	0493502
Document Type	C - Proceedings Paper (int. conf.)
R&D Document Type	The record was not marked in the RIV
Title	Determination of stability constants of antamanide complexes with sodium and potassium ions by affinity capillary electrophoresis
Author(s)	Pangavhane, Sachin (UOCHB-X) Böhm, S. (CZ) Makrlík, E. (CZ) Ruzza, P. (IT) Kašička, Václav (UOCHB-X)_{RID, ORCID}
Source Title	Advances in Chromatography and Electrophoresis & Chiranal 2018. - Olomouc : Palacký University, 2018 / Bednář P. ; Cechová M. ; Kučera L. ; Kurka O.
Pages	s. 103-104
Number of pages	2 s.
Publication form	Print - P
Action	Advances in Chromatography and Electrophoresis & Chiranal 2018
Event date	29.01.2018 - 01.02.2018
VEvent location	Olomouc
Country	CZ - Czech Republic
Event type	EUR
Language	eng - English
Country	CZ - Czech Republic
Keywords	affinity capillary electrophoresis ; antamanide ; binding constant
Subject RIV	CB - Analytical Chemistry, Separation
OECD category	Analytical chemistry
R&D Projects	GA15-01948S GA ČR - Czech Science Foundation (CSF)
Institutional support	UOCHB-X - RVO:61388963
Annotation	Affinity capillary electrophoresis (ACE) was applied for quantitative investigation of the interactions between important biomolecule, cyclic decapeptide antamanide (AA), cycl[-Val(1)-Pro(2)-Pro(3)-Ala(4)-Phe(5)-Phe(6)-Pro(7)-Pro(8)-Phe(9)-Phe(10)-], and sodium and potassium cations in methanol. Apparent stability constants of AA complexes with these alkali metal ions were determined from the dependence of effective mobility of AA on the concentration of these ions in the background electrolyte by the non-linear regression analysis. The AA complexes with Na+ and K+ ions were found to be relatively weak, with the apparent stability constants 343 L/mol and 35 L/mol, respectively.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434
Year of Publishing	2019

Number of the records: 1