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In-situ Observation of Lyophilization Process in Environmental Scanning Electron Microscope

SYSNO ASEP	0493330
Document Type	A - Abstract
R&D Document Type	The record was not marked in the RIV
R&D Document Type	Není vybrán druh dokumentu
Title	In-situ Observation of Lyophilization Process in Environmental Scanning Electron Microscope
Author(s)	Vetráková, L'. (CZ) Neděla, Vilém (UPT-D)_{RID, ORCID, SAI} Runštuk, Jiří (UPT-D)_{RID, SAI, ORCID}
Number of authors	3
Source Title	Microscopy and Microanalysis. - : Cambridge University Press - ISSN 1431-9276 Roč. 24, S1 (2018), s. 1406-1407
Number of pages	2 s.
Publication form	Print - P
Action	Microscopy & Microanalysis 2018 Meeting
Event date	05.08.2018 - 09.08.2018
VEvent location	Baltimore
Country	US - United States
Event type	WRD
Language	eng - English
Country	US - United States
Keywords	in-situ observation ; lyophilization process ; ESEM
Subject RIV	JA - Electronics ; Optoelectronics, Electrical Engineering
OECD category	Organic chemistry
R&D Projects	LO1212 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	ED0017/01/01 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UPT-D - RVO:68081731
DOI	10.1017/S1431927618007511
Annotation	Lyophilization (freeze-drying) is nowadays the most common formulation strategy to prepare pharmaceuticals as in the solid state chemical or physical degradation reactions are inhibited or sufficiently decelerated. However, it is a very time-consuming and expensive process. Lyophilisation at elevated temperatures can be used to accelerate the cost-intensive drying step and thus reduce the overall time and cost of the process (increase in temperature of 1 °C was reported to decrease the drying time by about 13%). Nonetheless, it is recommended to keep the product temperature just below the collapse temperature (Tc) during primary drying to avoid an undesirable collapse of a freeze-dried cake. Scanning electron microscopy (SEM) is usually used to examine the resulting morphology of the freeze-dried cake and to determine the product quality. However, SEM cannot be used to monitor the product structure during the lyophilisation process at the temperatures close to Tc due to difficulties with maintaining the SEM vacuum because of excessive ice sublimation. To monitor potential collapse, freeze-drying microscopy (FDM) is commonly applied.
Workplace	Institute of Scientific Instruments
Contact	Martina Šillerová, sillerova@ISIBrno.Cz, Tel.: 541 514 178
Year of Publishing	2019

Number of the records: 1