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Racemic Mixture Separation with Chiral Polymeric Membranes.
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SYSNO ASEP 0490481 Document Type C - Proceedings Paper (int. conf.) R&D Document Type The record was not marked in the RIV Title Racemic Mixture Separation with Chiral Polymeric Membranes. Author(s) Gaálová, Jana (UCHP-M) RID, SAI, ORCID
Stibor, Ivan (UCHP-M)
Cuřínová, Petra (UCHP-M) RID, SAI, ORCID
Žitka, Jan (UMCH-V) RID
Brožová, Libuše (UMCH-V) RID, ORCID
Otmar, Miroslav (UMCH-V) RID, ORCID
Sysel, P. (CZ)
Hovorka, Š. (CZ)
Izák, Pavel (UCHP-M) RID, ORCID, SAISource Title Book of Abstracts, Biofuels and biorefineries. - - : -, 2018 / Ban M. - ISSN 1847-7186 - ISBN N Pages s. 209 Number of pages 1 s. Publication form Print - P Action Latin American Conference on Sustainable Development of Energy, Water and Environmental Systems /1./ Event date 28.01.2018 - 31.01.2018 VEvent location Rio de Janeiro Country BR - Brazil Event type WRD Language eng - English Country BR - Brazil Keywords chiral polymeric membrane ; pharmaceutical industry ; pervaporation experiments Subject RIV CI - Industrial Chemistry, Chemical Engineering OECD category Chemical process engineering Subject RIV - cooperation Institute of Macromolecular Chemistry - Macromolecular Chemistry R&D Projects GA17-00089S GA ČR - Czech Science Foundation (CSF) Institutional support UCHP-M - RVO:67985858 ; UMCH-V - RVO:61389013 Annotation Drug stereochemistry has become an issue for the pharmaceutical industry and the regulatory authorities, because each of the enantiomers frequently shows different impacts to living organisms. The goal of the proposal is to develop new membrane separation techniques for successful resolution of racemic mixtures allowing optimization of the therapeutic value of enantiomeric drugs (pharmacological and toxicological) and avoiding their adverse effects. The key objective is to separate enantiomers by a new membrane separation method, based on the proposed “supported chiral room temperature ionic liquid membrane”, that has never been studied yet. In comparison with classical methods employed earlier, it should show higher efficiency and cost-effectiveness in the processes of enantiomer separation. To greatly reduce the amount of experimental work, particle-based modeling will be employed. After gathering all transport characteristics, it will be possible to model the separation process and to estimate
permeability and selectivity of the separation.Workplace Institute of Chemical Process Fundamentals Contact Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Year of Publishing 2019
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