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Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes
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SYSNO ASEP 0489875 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes Author(s) Kulig, W. (FI)
Mikkolainen, H. (FI)
Olžyńska, A. (CZ)
Jurkiewicz, P. (CZ)
Cwiklik, Lukasz (UOCHB-X) RID, ORCID
Hof, M. (CZ)
Vattulainen, I. (FI)
Jungwirth, Pavel (UOCHB-X) RID, ORCID
Rog, T. (FI)Source Title Journal of Physical Chemistry Letters. - : American Chemical Society - ISSN 1948-7185
Roč. 9, č. 5 (2018), s. 1118-1123Number of pages 6 s. Language eng - English Country US - United States Keywords oxysterols ; membranes ; molecular dynamics Subject RIV CF - Physical ; Theoretical Chemistry OECD category Physical chemistry R&D Projects GBP208/12/G016 GA ČR - Czech Science Foundation (CSF) EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UOCHB-X - RVO:61388963 UT WOS 000426803200029 EID SCOPUS 85042702390 DOI 10.1021/acs.jpclett.8b00211 Annotation Translocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Year of Publishing 2019
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