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Arbidol (Umifenovir): A broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses

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    SYSNO ASEP0489098
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleArbidol (Umifenovir): A broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses
    Author(s) Haviernik, J. (CZ)
    Štefánik, M. (CZ)
    Fojtíková, M. (CZ)
    Kali, S. (FR)
    Tordo, N. (FR)
    Rudolf, Ivo (UBO-W) RID, ORCID, SAI
    Hubálek, Zdeněk (UBO-W) RID, SAI, ORCID
    Eyer, Luděk (BC-A) RID, ORCID
    Růžek, Daniel (BC-A) RID, ORCID
    Number of authors9
    Article number184
    Source TitleViruses. - : MDPI
    Roč. 10, č. 4 (2018)
    Number of pages8 s.
    Languageeng - English
    CountryCH - Switzerland
    KeywordsAntiviral activity ; Arbidol ; Cell-type dependent antiviral effect ; Cytotoxicity ; Flavivirus ; Umifenovir
    Subject RIVEE - Microbiology, Virology
    OECD categoryVirology
    Subject RIV - cooperationBiology Centre (since 2006) - Microbiology, Virology
    R&D ProjectsGA16-20054S GA ČR - Czech Science Foundation (CSF)
    Method of publishingOpen access
    Institutional supportUBO-W - RVO:68081766 ; BC-A - RVO:60077344
    UT WOS000435184400045
    EID SCOPUS85045314142
    DOI10.3390/v10040184
    AnnotationArthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compound shows activities against numerous DNA and RNA viruses. The mode of action is based predominantly on impairment of critical steps in virus-cell interactions. Here we demonstrate that arbidol possesses micromolar-level anti-viral effects (EC 50 values ranging from 10.57 ± 0.74 to 19.16 ± 0.29 µM) in Vero cells infected with Zika virus, West Nile virus, and tick-borne encephalitis virus, three medically important representatives of the arthropod-borne flaviviruses. Interestingly, no antiviral effects of arbidol are observed in virus infected porcine stable kidney cells (PS), human neuroblastoma cells (UKF-NB-4), and human hepatoma cells (Huh-7 cells) indicating that the antiviral effect of arbidol is strongly cell-type dependent. Arbidol shows increasing cytotoxicity when tested in various cell lines, in the order: Huh-7 < HBCA < PS < UKF-NB-4 < Vero with CC 50 values ranging from 18.69 ± 0.1 to 89.72 ± 0.19 µM. Antiviral activities and acceptable cytotoxicity profiles suggest that arbidol could be a promising candidate for further investigation as a potential therapeutic agent in selective treatment of flaviviral infections.
    WorkplaceInstitute of Vertebrate Biology
    ContactHana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524
    Year of Publishing2019
    Electronic addresshttps://www.mdpi.com/1999-4915/10/4/184/pdf
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