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Arbidol (Umifenovir): A broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses
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SYSNO ASEP 0489098 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Arbidol (Umifenovir): A broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses Author(s) Haviernik, J. (CZ)
Štefánik, M. (CZ)
Fojtíková, M. (CZ)
Kali, S. (FR)
Tordo, N. (FR)
Rudolf, Ivo (UBO-W) RID, ORCID, SAI
Hubálek, Zdeněk (UBO-W) RID, SAI, ORCID
Eyer, Luděk (BC-A) RID, ORCID
Růžek, Daniel (BC-A) RID, ORCIDNumber of authors 9 Article number 184 Source Title Viruses. - : MDPI
Roč. 10, č. 4 (2018)Number of pages 8 s. Language eng - English Country CH - Switzerland Keywords Antiviral activity ; Arbidol ; Cell-type dependent antiviral effect ; Cytotoxicity ; Flavivirus ; Umifenovir Subject RIV EE - Microbiology, Virology OECD category Virology Subject RIV - cooperation Biology Centre (since 2006) - Microbiology, Virology R&D Projects GA16-20054S GA ČR - Czech Science Foundation (CSF) Method of publishing Open access Institutional support UBO-W - RVO:68081766 ; BC-A - RVO:60077344 UT WOS 000435184400045 EID SCOPUS 85045314142 DOI 10.3390/v10040184 Annotation Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compound shows activities against numerous DNA and RNA viruses. The mode of action is based predominantly on impairment of critical steps in virus-cell interactions. Here we demonstrate that arbidol possesses micromolar-level anti-viral effects (EC 50 values ranging from 10.57 ± 0.74 to 19.16 ± 0.29 µM) in Vero cells infected with Zika virus, West Nile virus, and tick-borne encephalitis virus, three medically important representatives of the arthropod-borne flaviviruses. Interestingly, no antiviral effects of arbidol are observed in virus infected porcine stable kidney cells (PS), human neuroblastoma cells (UKF-NB-4), and human hepatoma cells (Huh-7 cells) indicating that the antiviral effect of arbidol is strongly cell-type dependent. Arbidol shows increasing cytotoxicity when tested in various cell lines, in the order: Huh-7 < HBCA < PS < UKF-NB-4 < Vero with CC 50 values ranging from 18.69 ± 0.1 to 89.72 ± 0.19 µM. Antiviral activities and acceptable cytotoxicity profiles suggest that arbidol could be a promising candidate for further investigation as a potential therapeutic agent in selective treatment of flaviviral infections. Workplace Institute of Vertebrate Biology Contact Hana Slabáková, slabakova@ivb.cz, Tel.: 543 422 524 Year of Publishing 2019 Electronic address https://www.mdpi.com/1999-4915/10/4/184/pdf
Number of the records: 1