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Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria

SYSNO ASEP	0488571
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria
Author(s)	Hynek, Jan (UACH-T)_{SAI, RID, ORCID} Zelenka, J. (CZ) Rathouský, Jiří (UFCH-W)_{RID, ORCID} Kubát, Pavel (UFCH-W)_{RID, ORCID, SAI} Ruml, T. (CZ) Demel, Jan (UACH-T)_{SAI, RID, ORCID} Lang, Kamil (UACH-T)_{SAI, RID, ORCID}
Source Title	ACS Applied Materials and Interfaces. - : American Chemical Society - ISSN 1944-8244 Roč. 10, č. 10 (2018), s. 8527-8535
Number of pages	9 s.
Language	eng - English
Country	US - United States
Keywords	antibacterial coating ; biofilm ; covalent organic framework ; photodynamic ; porphyrin ; singlet oxygen
Subject RIV	CA - Inorganic Chemistry
OECD category	Inorganic and nuclear chemistry
Subject RIV - cooperation	J. Heyrovsky Institute of Physical Chemistry - Physical ; Theoretical Chemistry
R&D Projects	GA16-15020S GA ČR - Czech Science Foundation (CSF)
Institutional support	UACH-T - RVO:61388980 ; UFCH-W - RVO:61388955
UT WOS	000427910800016
EID SCOPUS	85043779819
DOI	10.1021/acsami.7b19835
Annotation	Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One of the possible approaches to prevent surfaces from the biofilm formation is antimicrobial photodynamic inactivation based on the cytotoxic effect of singlet oxygen, O 2 ( 1 Δ g ), a short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen. We synthesized porphyrin-based covalent organic frameworks (COFs) by Schiff-base chemistry. These novel COFs have a three-dimensional, diamond-like structure. The detailed analysis of their photophysical and photochemical properties shows that the COFs effectively produce O 2 ( 1 Δ g ) under visible light irradiation, and especially three-dimensional structures have strong antibacterial effects toward Pseudomonas aeruginosa and Enterococcus faecalis biofilms. The COFs exhibit high photostability and broad spectral efficiency. Hence, the porphyrinic COFs are suitable candidates for the design of antibacterial coating for indoor applications.
Workplace	Institute of Inorganic Chemistry
Contact	Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931
Year of Publishing	2019

Number of the records: 1