Number of the records: 1

Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes

SYSNO ASEP	0487732
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes
Author(s)	Kulig, W. (FI) Mikkolainen, H. (FI) Olžyńska, Agnieszka (UFCH-W)_RID Jurkiewicz, Piotr (UFCH-W)_{RID, ORCID} Cwiklik, Lukasz (UFCH-W)_{RID, ORCID} Hof, Martin (UFCH-W)_{RID, ORCID} Vattulainen, I. (FI) Jungwirth, P. (CZ) Rog, T. (FI)
Source Title	Journal of Physical Chemistry Letters. - : American Chemical Society - ISSN 1948-7185 Roč. 9, č. 5 (2018), s. 1118-1123
Number of pages	6 s.
Language	eng - English
Country	US - United States
Keywords	biological membranes ; alcohols ; cell membranes
Subject RIV	CF - Physical ; Theoretical Chemistry
OECD category	Physical chemistry
R&D Projects	GBP208/12/G016 GA ČR - Czech Science Foundation (CSF)
	EF16_019/0000729 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	UFCH-W - RVO:61388955
UT WOS	000426803200029
EID SCOPUS	85042702390
DOI	10.1021/acs.jpclett.8b00211
Annotation	Translocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action.
Workplace	J. Heyrovsky Institute of Physical Chemistry
Contact	Michaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
Year of Publishing	2019

Number of the records: 1