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Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes

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    SYSNO ASEP0487732
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleBobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes
    Author(s) Kulig, W. (FI)
    Mikkolainen, H. (FI)
    Olžyńska, Agnieszka (UFCH-W) RID
    Jurkiewicz, Piotr (UFCH-W) RID
    Cwiklik, Lukasz (UFCH-W) RID
    Hof, Martin (UFCH-W) RID
    Vattulainen, I. (FI)
    Jungwirth, P. (CZ)
    Rog, T. (FI)
    Source TitleJournal of Physical Chemistry Letters - ISSN 1948-7185
    Roč. 9, č. 5 (2018), s. 1118-1123
    Number of pages6 s.
    Languageeng - English
    CountryUS - United States
    Keywordsbiological membranes ; alcohols ; cell membranes
    Subject RIVCF - Physical ; Theoretical Chemistry
    OBOR OECDPhysical chemistry
    R&D ProjectsGBP208/12/G016 GA ČR - Czech Science Foundation (CSF)
    EF16_019/0000729 GA MŠk - Ministry of Education, Youth and Sports (MEYS)
    Institutional supportUFCH-W - RVO:61388955
    UT WOS000426803200029
    EID SCOPUS85042702390
    DOI10.1021/acs.jpclett.8b00211
    AnnotationTranslocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action.
    WorkplaceJ. Heyrovsky Institute of Physical Chemistry
    ContactMichaela Knapová, michaela.knapova@jh-inst.cas.cz, Tel.: 266 053 196
    Year of Publishing2019