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Probes & Drugs portal: an interactive, open data resource for chemical biology
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SYSNO ASEP 0487037 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Probes & Drugs portal: an interactive, open data resource for chemical biology Author(s) Škuta, Ctibor (UMG-J)
Popr, M. (CZ)
Muller, Tomáš (UMG-J)
Jindřich, Jindřich (UMG-J)
Kahle, Michal (UMG-J)
Sedlák, David (UMG-J) RID
Svozil, Daniel (UMG-J)
Bartůněk, Petr (UMG-J) RIDNumber of authors 8 Source Title Nature Methods. - : Nature Publishing Group - ISSN 1548-7091
Roč. 14, č. 8 (2017), s. 758-759Number of pages 2 s. Language eng - English Country US - United States Keywords bioactive compound, ,, ; chemical probe ; chemical biology ; portal Subject RIV EB - Genetics ; Molecular Biology OECD category Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8) R&D Projects LO1220 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UMG-J - RVO:68378050 UT WOS 000406493800005 DOI 10.1038/nmeth.4365 Annotation We report the Probes & Drugs (P&D) portal (https://www.probes-drugs.org), a powerful tool for the exploration of bioactive compound space. Chemical probes are indispensable tools in modern biology. These compounds are commonly used to study gene function, validate molecular targets or dissect complex processes within cells and organisms1,2,3. Unlike drugs, which are effective, bioavailable and safe compounds, a probe's main attributes reside in its potency, selectivity and well-defined mechanism of action. Yet identifying chemical probes that meet all the demands of an experimental design is not a trivial task. Information on candidate probes and their potency, mechanism of action or availability is typically scattered over various sources, and gathering such information can be very time consuming. In some cases, probe annotations may even be out of date, and this propagates the continued selection of probes in which the biological characteristics have been disproven and their suitability questioned4,5. Many of these compounds remain incorporated in commercial screening libraries and continue to be used by the community5,6. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2018
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